| Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors E Reiter, S Ahn, AK Shukla, RJ Lefkowitz Annual review of pharmacology and toxicology 52, 179-197, 2012 | 491 | 2012 |
| Distinct phosphorylation sites on the β2-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin KN Nobles, K Xiao, S Ahn, AK Shukla, CM Lam, S Rajagopal, ... Sci. Signal. 4 (185), ra51-ra51, 2011 | 406 | 2011 |
| Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling AK Shukla, K Xiao, RJ Lefkowitz Trends in biochemical sciences 36 (9), 457-469, 2011 | 379 | 2011 |
| Functional specialization of β-arrestin interactions revealed by proteomic analysis K Xiao, DB McClatchy, AK Shukla, Y Zhao, M Chen, SK Shenoy, JR Yates, ... Proceedings of the National Academy of Sciences 104 (29), 12011-12016, 2007 | 347 | 2007 |
| Visualization of arrestin recruitment by a G-protein-coupled receptor AK Shukla, GH Westfield, K Xiao, RI Reis, LY Huang, P Tripathi-Shukla, ... Nature 512 (7513), 218, 2014 | 295 | 2014 |
| Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide AK Shukla, A Manglik, AC Kruse, K Xiao, RI Reis, WC Tseng, DP Staus, ... Nature 497 (7447), 137, 2013 | 267 | 2013 |
| GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling ARB Thomsen, B Plouffe, TJ Cahill III, AK Shukla, JT Tarrasch, AM Dosey, ... Cell 166 (4), 907-919, 2016 | 226 | 2016 |
| β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice RW Walters, AK Shukla, JJ Kovacs, JD Violin, SM DeWire, CM Lam, ... The Journal of clinical investigation 119 (5), 1312-1321, 2009 | 215 | 2009 |
| Multiple ligand-specific conformations of the β2-adrenergic receptor AW Kahsai, K Xiao, S Rajagopal, S Ahn, AK Shukla, J Sun, TG Oas, ... Nature chemical biology 7 (10), 692, 2011 | 208 | 2011 |
| Distinct conformational changes in β-arrestin report biased agonism at seven-transmembrane receptors AK Shukla, JD Violin, EJ Whalen, D Gesty-Palmer, SK Shenoy, ... Proceedings of the National Academy of Sciences 105 (29), 9988-9993, 2008 | 208 | 2008 |
| Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR) K Xiao, J Sun, J Kim, S Rajagopal, B Zhai, J Villén, W Haas, JJ Kovacs, ... Proceedings of the National Academy of Sciences 107 (34), 15299-15304, 2010 | 193 | 2010 |
| Methodological advances: the unsung heroes of the GPCR structural revolution E Ghosh, P Kumari, D Jaiman, AK Shukla Nature Reviews Molecular Cell Biology 16 (2), 69-81, 2015 | 153 | 2015 |
| β-Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2 SK Shenoy, AS Modi, AK Shukla, K Xiao, M Berthouze, S Ahn, ... Proceedings of the National Academy of Sciences 106 (16), 6650-6655, 2009 | 143 | 2009 |
| β-Arrestin–dependent activation of Ca2+/calmodulin kinase II after β1–adrenergic receptor stimulation S Mangmool, AK Shukla, HA Rockman The Journal of cell biology 189 (3), 573-587, 2010 | 135 | 2010 |
| Ubiquitination of β-arrestin links seven-transmembrane receptor endocytosis and ERK activation SK Shenoy, LS Barak, K Xiao, S Ahn, M Berthouze, AK Shukla, LM Luttrell, ... Journal of Biological Chemistry 282 (40), 29549-29562, 2007 | 117 | 2007 |
| Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis TJ Cahill, ARB Thomsen, JT Tarrasch, B Plouffe, AH Nguyen, F Yang, ... Proceedings of the National Academy of Sciences 114 (10), 2562-2567, 2017 | 116 | 2017 |
| The structure of the neuropeptide bradykinin bound to the human G‐protein coupled receptor bradykinin B2 as determined by solid‐state NMR spectroscopy JJ Lopez, AK Shukla, C Reinhart, H Schwalbe, H Michel, C Glaubitz Angewandte Chemie International Edition 47 (9), 1668-1671, 2008 | 94 | 2008 |
| Emerging structural insights into biased GPCR signaling AK Shukla, G Singh, E Ghosh Trends in biochemical sciences 39 (12), 594-602, 2014 | 77 | 2014 |
| Arresting a Transient Receptor Potential (TRP) Channel β-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4 AK Shukla, J Kim, S Ahn, K Xiao, SK Shenoy, W Liedtke, RJ Lefkowitz Journal of Biological Chemistry 285 (39), 30115-30125, 2010 | 71 | 2010 |
| Functional competence of a partially engaged GPCR–β-arrestin complex P Kumari, A Srivastava, R Banerjee, E Ghosh, P Gupta, R Ranjan, X Chen, ... Nature communications 7, 13416, 2016 | 66 | 2016 |
