| Amyloid-β dynamics are regulated by orexin and the sleep-wake cycle JE Kang, MM Lim, RJ Bateman, JJ Lee, LP Smyth, JR Cirrito, N Fujiki, ... Science 326 (5955), 1005-1007, 2009 | 1605 | 2009 |
| TREM2 lipid sensing sustains the microglial response in an Alzheimer’s disease model Y Wang, M Cella, K Mallinson, JD Ulrich, KL Young, ML Robinette, ... Cell 160 (6), 1061-1071, 2015 | 1515 | 2015 |
| Synaptic activity regulates interstitial fluid amyloid-β levels in vivo JR Cirrito, KA Yamada, MB Finn, RS Sloviter, KR Bales, PC May, ... Neuron 48 (6), 913-922, 2005 | 1409 | 2005 |
| ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models PE Cramer, JR Cirrito, DW Wesson, CYD Lee, JC Karlo, AE Zinn, ... science 335 (6075), 1503-1506, 2012 | 1234 | 2012 |
| Neuronal activity regulates the regional vulnerability to amyloid-β deposition AW Bero, P Yan, JH Roh, JR Cirrito, FR Stewart, ME Raichle, JM Lee, ... Nature neuroscience 14 (6), 750-756, 2011 | 921 | 2011 |
| P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model JR Cirrito, R Deane, AM Fagan, ML Spinner, M Parsadanian, MB Finn, ... The Journal of clinical investigation 115 (11), 3285-3290, 2005 | 763 | 2005 |
| TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques Y Wang, TK Ulland, JD Ulrich, W Song, JA Tzaferis, JT Hole, P Yuan, ... Journal of Experimental Medicine 213 (5), 667-675, 2016 | 726 | 2016 |
| Endocytosis is required for synaptic activity-dependent release of amyloid-β in vivo JR Cirrito, JE Kang, J Lee, FR Stewart, DK Verges, LM Silverio, G Bu, ... Neuron 58 (1), 42-51, 2008 | 709 | 2008 |
| Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer’s disease model PE Sanchez, L Zhu, L Verret, KA Vossel, AG Orr, JR Cirrito, N Devidze, ... Proceedings of the National Academy of Sciences 109 (42), E2895-E2903, 2012 | 661 | 2012 |
| The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans JK Holth, SK Fritschi, C Wang, NP Pedersen, JR Cirrito, TE Mahan, ... Science 363 (6429), 880-884, 2019 | 594 | 2019 |
| In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-β metabolism and half-life JR Cirrito, PC May, MA O'Dell, JW Taylor, M Parsadanian, JW Cramer, ... Journal of Neuroscience 23 (26), 8844-8853, 2003 | 570 | 2003 |
| ApoE and clusterin cooperatively suppress Aβ levels and deposition: evidence that ApoE regulates extracellular Aβ metabolism in vivo RB DeMattos, JR Cirrito, M Parsadanian, PC May, MA O'Dell, JW Taylor, ... Neuron 41 (2), 193-202, 2004 | 548 | 2004 |
| Neuronal activity regulates extracellular tau in vivo K Yamada, JK Holth, F Liao, FR Stewart, TE Mahan, H Jiang, JR Cirrito, ... Journal of Experimental Medicine 211 (3), 387-393, 2014 | 537 | 2014 |
| Matrix metalloproteinase-9 degrades amyloid-β fibrils in vitro and compact plaques in situ P Yan, X Hu, H Song, K Yin, RJ Bateman, JR Cirrito, Q Xiao, FF Hsu, ... Journal of Biological Chemistry 281 (34), 24566-24574, 2006 | 417 | 2006 |
| Matrix metalloproteinases expressed by astrocytes mediate extracellular amyloid-β peptide catabolism KJ Yin, JR Cirrito, P Yan, X Hu, Q Xiao, X Pan, R Bateman, H Song, ... Journal of Neuroscience 26 (43), 10939-10948, 2006 | 410 | 2006 |
| In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice K Yamada, JR Cirrito, FR Stewart, H Jiang, MB Finn, BB Holmes, ... Journal of Neuroscience 31 (37), 13110-13117, 2011 | 389 | 2011 |
| Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans JR Cirrito, BM Disabato, JL Restivo, DK Verges, WD Goebel, A Sathyan, ... Proceedings of the National Academy of Sciences 108 (36), 14968-14973, 2011 | 358 | 2011 |
| Amyloid‐beta oligomerization in Alzheimer dementia versus high‐pathology controls TJ Esparza, H Zhao, JR Cirrito, NJ Cairns, RJ Bateman, DM Holtzman, ... Annals of neurology 73 (1), 104-119, 2013 | 357 | 2013 |
| Antisense reduction of tau in adult mice protects against seizures SL DeVos, DK Goncharoff, G Chen, CS Kebodeaux, K Yamada, ... Journal of Neuroscience 33 (31), 12887-12897, 2013 | 335 | 2013 |
| Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice AW Kraft, X Hu, H Yoon, P Yan, Q Xiao, Y Wang, SC Gil, J Brown, ... The FASEB Journal 27 (1), 187, 2013 | 316 | 2013 |
