| Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells C Lopez-Sambrooks, S Shrimal, C Khodier, DP Flaherty, N Rinis, ... Nature chemical biology 12 (12), 1023-1030, 2016 | 97 | 2016 |
| Congruent release of drug and polymer from amorphous solid dispersions: insights into the role of drug-polymer hydrogen bonding, surface crystallization, and glass transition S Saboo, US Kestur, DP Flaherty, LS Taylor Molecular pharmaceutics 17 (4), 1261-1275, 2020 | 86 | 2020 |
| Polyfluorinated bis-styrylbenzene β-amyloid plaque binding ligands DP Flaherty, SM Walsh, T Kiyota, Y Dong, T Ikezu, JL Vennerstrom Journal of medicinal chemistry 50 (20), 4986-4992, 2007 | 76 | 2007 |
| Optimization of Acetazolamide-Based Scaffold as Potent Inhibitors of Vancomycin-Resistant Enterococcus J Kaur, X Cao, NS Abutaleb, A Elkashif, AL Graboski, AD Krabill, ... Journal of medicinal chemistry 63 (17), 9540-9562, 2020 | 65 | 2020 |
| Repurposing the Antihistamine Terfenadine for Antimicrobial Activity against Staphylococcus aureus JI Perlmutter, LT Forbes, DJ Krysan, K Ebsworth-Mojica, JM Colquhoun, ... Journal of medicinal chemistry 57 (20), 8540-8562, 2014 | 61 | 2014 |
| Structure–Activity Relationship Studies of Acetazolamide-Based Carbonic Anhydrase Inhibitors with Activity against Neisseria gonorrhoeae CS Hewitt, NS Abutaleb, AEM Elhassanny, A Nocentini, X Cao, DP Amos, ... ACS infectious diseases 7 (7), 1969-1984, 2021 | 54 | 2021 |
| Interrogating a hexokinase-selected small-molecule library for inhibitors of Plasmodium falciparum hexokinase MT Harris, DM Walker, ME Drew, WG Mitchell, K Dao, CE Schroeder, ... Antimicrobial agents and chemotherapy 57 (8), 3731-3737, 2013 | 50 | 2013 |
| Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers DP Flaherty, T Kiyota, Y Dong, T Ikezu, JL Vennerstrom Journal of medicinal chemistry 53 (22), 7992-7999, 2010 | 49 | 2010 |
| Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold DP Flaherty, DS Simpson, M Miller, BE Maki, B Zou, J Shi, M Wu, ... Bioorganic & medicinal chemistry letters 24 (16), 3968-3973, 2014 | 46 | 2014 |
| Ubiquitin C‐Terminal Hydrolase L1: Biochemical and Cellular Characterization of a Covalent Cyanopyrrolidine‐Based Inhibitor AD Krabill, H Chen, S Hussain, C Feng, A Abdullah, C Das, UK Aryal, ... ChemBioChem 21 (5), 712-722, 2020 | 34 | 2020 |
| In vitro and in vivo activities of the carbonic anhydrase inhibitor, dorzolamide, against vancomycin-resistant enterococci NS Abutaleb, AEM Elhassanny, DP Flaherty, MN Seleem PeerJ 9, e11059, 2021 | 33 | 2021 |
| Optimization of a 1, 3, 4-oxadiazole series for inhibition of Ca2+/calmodulin-stimulated activity of adenylyl cyclases 1 and 8 for the treatment of chronic pain J Kaur, M Soto-Velasquez, Z Ding, A Ghanbarpour, MA Lill, RM van Rijn, ... European journal of medicinal chemistry 162, 568-585, 2019 | 33 | 2019 |
| In Vivo Antibacterial Activity of Acetazolamide NS Abutaleb, A Elkashif, DP Flaherty, MN Seleem Antimicrobial Agents and Chemotherapy 65 (4), 10.1128/aac. 01715-20, 2021 | 32 | 2021 |
| Optimization of potent and selective quinazolinediones: inhibitors of respiratory syncytial virus that block RNA-dependent RNA-polymerase complex activity DS Matharu, DP Flaherty, DS Simpson, CE Schroeder, D Chung, D Yan, ... Journal of medicinal chemistry 57 (24), 10314-10328, 2014 | 29 | 2014 |
| Coumarins effectively inhibit bacterial α-carbonic anhydrases S Giovannuzzi, CS Hewitt, A Nocentini, C Capasso, DP Flaherty, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 333-338, 2022 | 27 | 2022 |
| Repurposing FDA-approved sulphonamide carbonic anhydrase inhibitors for treatment of Neisseria gonorrhoeae NS Abutaleb, AEM Elhassanny, A Nocentini, CS Hewitt, A Elkashif, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 51-61, 2022 | 26 | 2022 |
| ML365: Development of bis-amides as selective inhibitors of the KCNK3/TASK1 two pore potassium channel B Zou, DP Flaherty, DS Simpson, BE Maki, MR Miller, J Shi, M Wu, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2013 | 26 | 2013 |
| Structure-activity relationship studies for inhibitors for vancomycin-resistant Enterococcus and human carbonic anhydrases W An, KJ Holly, A Nocentini, RD Imhoff, CS Hewitt, NS Abutaleb, X Cao, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 1838-1844, 2022 | 21 | 2022 |
| Discovery of sulfonamidebenzamides as selective apoptotic CHOP pathway activators of the unfolded protein response DP Flaherty, JR Miller, DM Garshott, M Hedrick, P Gosalia, Y Li, ... ACS medicinal chemistry letters 5 (12), 1278-1283, 2014 | 19 | 2014 |
| Inhibition studies of bacterial α-carbonic anhydrases with phenols S Giovannuzzi, CS Hewitt, A Nocentini, C Capasso, G Costantino, ... Journal of Enzyme Inhibition and Medicinal Chemistry 37 (1), 666-671, 2022 | 18 | 2022 |
