The β-lactamase gene regulator AmpR is a tetramer that recognizes and binds the D-Ala-D-Ala motif of its repressor UDP-N-acetylmuramic acid (MurNAc)-pentapeptide G Vadlamani, MD Thomas, TR Patel, LJ Donald, TM Reeve, J Stetefeld, ... Journal of biological chemistry 290 (5), 2630-2643, 2015 | 78 | 2015 |
Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams M Mondon, S Hur, G Vadlamani, P Rodrigues, P Tsybina, A Oliver, ... Chemical communications 49 (93), 10983-10985, 2013 | 46 | 2013 |
The structure of a conserved domain of TamB reveals a hydrophobic β taco fold I Josts, CJ Stubenrauch, G Vadlamani, K Mosbahi, D Walker, T Lithgow, ... Structure 25 (12), 1898-1906. e5, 2017 | 41 | 2017 |
Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa M Hamou-Segarra, L Zamorano, G Vadlamani, M Chu, I Sanchez-Diener, ... Journal of Antimicrobial Chemotherapy 72 (2), 448-454, 2017 | 30 | 2017 |
N-Acetyl glycals are tight-binding and environmentally insensitive inhibitors of hexosaminidases AG Santana, G Vadlamani, BL Mark, SG Withers Chemical communications 52 (51), 7943-7946, 2016 | 27 | 2016 |
Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β‐lactam antibiotic resistance G Vadlamani, KA Stubbs, J Désiré, Y Blériot, DJ Vocadlo, BL Mark Protein Science 26 (6), 1161-1170, 2017 | 19 | 2017 |
Antibiotic resistance lessons for the herbicide resistance crisis J Haywood, G Vadlamani, KA Stubbs, JS Mylne Pest Management Science 77 (9), 3807-3814, 2021 | 18 | 2021 |
Selective trihydroxylated azepane inhibitors of NagZ, a glycosidase involved in Pseudomonas aeruginosa resistance to β-lactam antibiotics J Bouquet, DT King, G Vadlamani, GR Benzie, B Iorga, D Ide, I Adachi, ... Organic & biomolecular chemistry 15 (21), 4609-4619, 2017 | 16 | 2017 |
A chameleonic macrocyclic peptide with drug delivery applications CD Payne, B Franke, MF Fisher, F Hajiaghaalipour, CE McAleese, ... Chemical science 12 (19), 6670-6683, 2021 | 12 | 2021 |
Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam CS Mangat, G Vadlamani, V Holicek, M Chu, VLC Larmour, DJ Vocadlo, ... Antimicrobial Agents and Chemotherapy 63 (4), 10.1128/aac. 02112-18, 2019 | 7 | 2019 |
The carbapenemase BKC-1 from Klebsiella pneumoniae is adapted for translocation by both the Tat and Sec translocons M Bharathwaj, CT Webb, G Vadlamani, CJ Stubenrauch, T Palmer, ... MBio 12 (3), 10.1128/mbio. 01302-21, 2021 | 6 | 2021 |
Defining the familial fold of the vicilin-buried peptide family CD Payne, G Vadlamani, MF Fisher, J Zhang, RJ Clark, JS Mylne, ... Journal of Natural Products 83 (10), 3030-3040, 2020 | 6 | 2020 |
Crystal structure of Arabidopsis thaliana HPPK/DHPS, a bifunctional enzyme and target of the herbicide asulam G Vadlamani, KV Sukhoverkov, J Haywood, KJ Breese, MF Fisher, ... Plant Communications 3 (4), 2022 | 3 | 2022 |
Solution NMR and racemic crystallography provide insights into a novel structural class of cyclic plant peptides CD Payne, G Vadlamani, F Hajiaghaalipour, T Muhammad, MF Fisher, ... RSC chemical biology 2 (6), 1682-1691, 2021 | 3 | 2021 |
Molecular grafting can generate bioactivities within the cyclic peptide PDP-23 F Hajiaghaalipour, A Song, G Vadlamani, J Zhang, J Mylne, R Clark, ... | | 2023 |