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Elçin Içten
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Dropwise Additive Manufacturing of Pharmaceutical Products for Melt‐Based Dosage Forms
E Içten, A Giridhar, LS Taylor, ZK Nagy, GV Reklaitis
Journal of pharmaceutical sciences 104 (5), 1641-1649, 2015
882015
Dropwise additive manufacturing of pharmaceutical products for amorphous and self emulsifying drug delivery systems
E Içten, HS Purohit, C Wallace, A Giridhar, LS Taylor, ZK Nagy, ...
International journal of pharmaceutics 524 (1-2), 424-432, 2017
502017
Process control of a dropwise additive manufacturing system for pharmaceuticals using polynomial chaos expansion based surrogate model
E Içten, ZK Nagy, GV Reklaitis
Computers & Chemical Engineering 83, 221-231, 2015
432015
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 3: Manganese-Catalyzed Asymmetric Epoxidation, Crystallization, and …
AJ Maloney, E Içten, G Capellades, MG Beaver, X Zhu, LR Graham, ...
Organic Process Research & Development 24 (10), 1891-1908, 2020
282020
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 1: CDI-Promoted Amide Bond Formation
E Içten, AJ Maloney, MG Beaver, DE Shen, X Zhu, LR Graham, ...
Organic Process Research & Development 24 (10), 1861-1875, 2020
272020
Continuous process improvement in the manufacture of Carfilzomib, part 2: an improved process for synthesis of the Epoxyketone warhead
MG Beaver, X Shi, J Riedel, P Patel, A Zeng, MT Corbett, JA Robinson, ...
Organic Process Research & Development 24 (4), 490-499, 2020
222020
A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process
E Içten, AJ Maloney, MG Beaver, X Zhu, DE Shen, JA Robinson, ...
Organic Process Research & Development 24 (10), 1876-1890, 2020
212020
Real-time process management strategy for dropwise additive manufacturing of pharmaceutical products
L Hirshfield, E Içten, A Giridhar, ZK Nagy, GV Reklaitis
Journal of Pharmaceutical Innovation 10, 140-155, 2015
212015
Drop-on-demand system for manufacturing of melt-based solid oral dosage: effect of critical process parameters on product quality
E Içten, A Giridhar, ZK Nagy, GV Reklaitis
AAPS PharmSciTech 17, 284-293, 2016
182016
Supervisory Control of a Drop on Demand Mini-manufacturing System for Pharmaceuticals
E Icten, ZK Nagy, GV Reklaitis
Computer Aided Chemical Engineering 33, 535-540, 2014
122014
Knowledge provenance management system for a dropwise additive manufacturing system for pharmaceutical products
E Içten, G Joglekar, C Wallace, K Loehr, J Sacksteder, A Giridhar, ...
Industrial & Engineering Chemistry Research 55 (36), 9676-9686, 2016
112016
Guidelines for extracting biologically relevant context-specific metabolic models using gene expression data
S Gopalakrishnan, CJ Joshi, MÁ Valderrama-Gómez, E Icten, P Rolandi, ...
Metabolic Engineering 75, 181-191, 2023
82023
Advanced control for the continuous dropwise additive manufacturing of pharmaceutical products
E Içten, GV Reklaitis, ZK Nagy
Computer Aided Chemical Engineering 41, 379-401, 2018
62018
Green Chemistry as a Driver for Innovation in the Pharmaceutical Industry
MG Beaver, S Caille, E Içten, SE Michalak, G St‐Pierre, OR Thiel
Israel Journal of Chemistry 61 (7-8), 369-379, 2021
42021
Application of a Knowledge Management System to a Dropwise Additive Manufacturing System for Pharmaceuticals
E Içten, GS Joglekar, A Giridhar, GV Reklaitis
Computer Aided Chemical Engineering 38, 619-624, 2016
42016
Modelling of Crystallization of Solid Oral Drug Forms in a Dropwise Additive Manufacturing System
E Içten, ZK Nagy, GV Reklaitis
Computer Aided Chemical Engineering 37, 2195-2200, 2015
42015
COSMIC-dFBA: A novel multi-scale hybrid framework for bioprocess modeling
S Gopalakrishnan, W Johnson, MA Valderrama-Gomez, E Icten, J Tat, ...
Metabolic Engineering, 2024
12024
Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks
S Gopalakrishnan, W Johnson, MAV Gomez, E Icten, J Tat, F Lay, J Diep, ...
bioRxiv, 2023.09. 13.557626, 2023
12023
Methods and systems for depositing active ingredients on substrates
AV Giridhar, M Harris, GV Reklaitis, LS Taylor, ZK Nagy, E Icten, F Fiesser, ...
US Patent App. 18/152,394, 2023
2023
Methods and systems for depositing active ingredients on substrates
AV Giridhar, M Harris, GV Reklaitis, LS Taylor, ZK Nagy, E Icten, F Fiesser, ...
US Patent 11,547,675, 2023
2023
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