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Brian C. Capell, MD, PhD
Brian C. Capell, MD, PhD
Assistant Professor of Dermatology and Genetics, University of Pennsylvania
Verified email at uphs.upenn.edu
Title
Cited by
Cited by
Year
Cytoplasmic chromatin triggers inflammation in senescence and cancer
Z Dou, K Ghosh, MG Vizioli, J Zhu, P Sen, KJ Wangensteen, J Simithy, ...
Nature 550 (7676), 402-406, 2017
10202017
Human laminopathies: nuclei gone genetically awry
BC Capell, FS Collins
Nature reviews genetics 7 (12), 940-952, 2006
6172006
Autophagy mediates degradation of nuclear lamina
Z Dou, C Xu, G Donahue, T Shimi, JA Pan, J Zhu, A Ivanov, BC Capell, ...
Nature 527 (7576), 105-109, 2015
6052015
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
PP Shah, G Donahue, GL Otte, BC Capell, DM Nelson, K Cao, ...
Genes & development 27 (16), 1787-1799, 2013
5282013
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome
BC Capell, MR Erdos, JP Madigan, JJ Fiordalisi, R Varga, KN Conneely, ...
Proceedings of the National Academy of Sciences 102 (36), 12879-12884, 2005
4552005
A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells
K Cao, BC Capell, MR Erdos, K Djabali, FS Collins
Proceedings of the National Academy of Sciences 104 (12), 4949-4954, 2007
3112007
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson–Gilford progeria syndrome
R Varga, M Eriksson, MR Erdos, M Olive, I Harten, F Kolodgie, BC Capell, ...
Proceedings of the National Academy of Sciences 103 (9), 3250-3255, 2006
2932006
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
BC Capell, M Olive, MR Erdos, K Cao, DA Faddah, UL Tavarez, ...
Proceedings of the National Academy of Sciences 105 (41), 15902-15907, 2008
2312008
Mechanisms of cardiovascular disease in accelerated aging syndromes
BC Capell, FS Collins, EG Nabel
Circulation Research 101 (1), 13-26, 2007
1522007
Magnetic resonance imaging in quantitative analysis of rotator cuff muscle volume.
MJ Tingart, M Apreleva, JT Lehtinen, B Capell, WE Palmer, JJP Warner
Clinical Orthopaedics and Related Research (1976-2007) 415, 104-110, 2003
1472003
MLL1 is essential for the senescence-associated secretory phenotype
BC Capell, AM Drake, J Zhu, PP Shah, Z Dou, J Dorsey, DF Simola, ...
Genes & development 30 (3), 321-336, 2016
1452016
The senescence-associated secretory phenotype: critical effector in skin cancer and aging
K Ghosh, BC Capell
Journal of Investigative Dermatology 136 (11), 2133-2139, 2016
1402016
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
AS McNeal, K Liu, V Nakhate, CA Natale, EK Duperret, BC Capell, ...
Cancer discovery 5 (10), 1072-1085, 2015
1062015
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
E Lin-Shiao, Y Lan, M Coradin, A Anderson, G Donahue, CL Simpson, ...
Genes & development 32 (2), 181-193, 2018
862018
Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
VLRM Verstraeten, LA Peckham, M Olive, BC Capell, FS Collins, ...
Proceedings of the National Academy of Sciences 108 (12), 4997-5002, 2011
842011
From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging
BC Capell, BE Tlougan, SJ Orlow
Journal of Investigative Dermatology 129 (10), 2340-2350, 2009
632009
LSD1 inhibition promotes epithelial differentiation through derepression of fate-determining transcription factors
S Egolf, Y Aubert, M Doepner, A Anderson, A Maldonado-Lopez, ...
Cell reports 28 (8), 1981-1992. e7, 2019
592019
Human longevity and common variations in the LMNA gene: a meta‐analysis
KN Conneely, BC Capell, MR Erdos, P Sebastiani, N Solovieff, AJ Swift, ...
Aging cell 11 (3), 475-481, 2012
532012
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization
S Huang, P Kuri, Y Aubert, M Brewster, N Li, O Farrelly, G Rice, H Bae, ...
Cell Stem Cell 28 (9), 1582-1596. e6, 2021
522021
Pharmacologic activation of the G protein–coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
CA Natale, J Li, JR Pitarresi, RJ Norgard, T Dentchev, BC Capell, ...
Cellular and Molecular Gastroenterology and Hepatology 10 (4), 868-880. e1, 2020
452020
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