| The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence LE Klein, BS Freeze, AB Smith III, SB Horwitz Cell Cycle 4 (3), 501-507, 2005 | 132 | 2005 |
| Potentiation of taxol efficacy by discodermolide in ovarian carcinoma xenograft-bearing mice GS Huang, L Lopez-Barcons, BS Freeze, AB Smith III, GL Goldberg, ... Clinical cancer research 12 (1), 298-304, 2006 | 117 | 2006 |
| Discovery of TAK-981, a first-in-class inhibitor of SUMO-activating enzyme for the treatment of cancer SP Langston, S Grossman, D England, R Afroze, N Bence, D Bowman, ... Journal of medicinal chemistry 64 (5), 2501-2520, 2021 | 100 | 2021 |
| (+)-Discodermolide: total synthesis, construction of novel analogues, and biological evaluation AB Smith III, BS Freeze Tetrahedron 64 (2), 261-298, 2008 | 93 | 2008 |
| Total synthesis of (+)-discodermolide: a highly convergent fourth-generation approach AB Smith, BS Freeze, M Xian, T Hirose Organic letters 7 (9), 1825-1828, 2005 | 74 | 2005 |
| A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach AB Smith, BS Freeze, I Brouard, T Hirose Organic Letters 5 (23), 4405-4408, 2003 | 72 | 2003 |
| Toward understanding how the lactone moiety of discodermolide affects activity SJ Shaw, KF Sundermann, MA Burlingame, DC Myles, BS Freeze, M Xian, ... Journal of the American Chemical Society 127 (18), 6532-6533, 2005 | 64 | 2005 |
| Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide AB Smith, BS Freeze, MJ LaMarche, T Hirose, I Brouard, PV Rucker, ... Organic Letters 7 (2), 311-314, 2005 | 56 | 2005 |
| Discodermolide analogues as the chemical component of combination bacteriolytic therapy AB Smith III, BS Freeze, MJ LaMarche, J Sager, KW Kinzler, B Vogelstein Bioorganic & medicinal chemistry letters 15 (15), 3623-3626, 2005 | 48 | 2005 |
| Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide AB Smith, BS Freeze, MJ LaMarche, T Hirose, I Brouard, M Xian, ... Organic letters 7 (2), 315-318, 2005 | 46 | 2005 |
| Design, synthesis, and evaluation of naphthalene-sulfonamide antagonists of human CCR8 TJ Jenkins, B Guan, M Dai, G Li, TE Lightburn, S Huang, BS Freeze, ... Journal of medicinal chemistry 50 (3), 566-584, 2007 | 41 | 2007 |
| Synthesis of carbohydrate-derived 1, 2, 3-triazoles using 1, 3-dipolar cycloaddition on a soluble polymer support S Freeze, P Norris Heterocycles 8 (51), 1807-1817, 1999 | 36 | 1999 |
| Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes AB Smith, PV Rucker, I Brouard, BS Freeze, S Xia, SB Horwitz Organic letters 7 (23), 5199-5202, 2005 | 33 | 2005 |
| Design, synthesis and cytotoxicity of 7-deoxy aryl discodermolide analogues MA Burlingame, SJ Shaw, KF Sundermann, D Zhang, J Petryka, ... Bioorganic & medicinal chemistry letters 14 (9), 2335-2338, 2004 | 30 | 2004 |
| Facile Assembly of 2, 4-Orthogonally-Functionalized Oxazoles: Useful Bidirectional Linchpins AB Smith III, KP Minbiole, S Freeze Synlett 2001 (11), 1739-1742, 2001 | 23 | 2001 |
| Heteroaryl compounds useful as inhibitors of SUMO activating enzyme MO Duffey, D England, S Freeze, Z Hu, S Langston, C McIntyre, ... US Patent 9,683,003, 2017 | 17 | 2017 |
| Heteroaryls and uses thereof BS Freeze, M Hirose, Y Hu, TB Sells, Z Shi, S Vyskocil, T Xu US Patent 8,796,268, 2014 | 9 | 2014 |
| Heteroaryls and uses thereof BS Freeze, M Hirose, HM Lee, TB Sells, Z Shi, LR Takaoka, S Vyskocil, ... US Patent 8,765,746, 2014 | 8 | 2014 |
| Synthesis of A Partially Protected Azidodeoxy Sugar: A Project Suitable for the Advanced Undergraduate Organic Chemistry Laboratory P Norris, S Freeze, CJ Gabriel Journal of Chemical Education 78 (1), 75-76, 2001 | 7 | 2001 |
| Heteroaryl compounds useful as inhibitors of SUMO activating enzyme MO Duffey, D England, BS Freeze, Z Hu, S Langston, C McIntyre, ... US Patent 9,962,386, 2018 | 3 | 2018 |
