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Kaushik Ghosh
Kaushik Ghosh
Assoc Research Director, Biocon Bristol-Myers Squibb R&D center
Verified email at syngeneintl.com - Homepage
Title
Cited by
Cited by
Year
Cre–loxP biochemistry
K Ghosh, GD Van Duyne
Methods 28 (3), 374-383, 2002
1592002
Requirements for catalysis in the Cre recombinase active site
B Gibb, K Gupta, K Ghosh, R Sharp, J Chen, GD Van Duyne
Nucleic acids research 38 (17), 5817-5832, 2010
962010
Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination
K Ghosh, CK Lau, F Guo, AM Segall, GD Van Duyne
Journal of Biological Chemistry 280 (9), 8290-8299, 2005
672005
Synapsis of loxP sites by Cre recombinase
K Ghosh, F Guo, GD Van Duyne
Journal of Biological Chemistry 282 (33), 24004-24016, 2007
632007
Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination
K Ghosh, CK Lau, K Gupta, GD Van Duyne
Nature chemical biology 1 (5), 275-282, 2005
572005
Crystal structure of rat intestinal alkaline phosphatase–role of crown domain in mammalian alkaline phosphatases
K Ghosh, DM Tagore, R Anumula, B Lakshmaiah, P Kumar, S Singaram, ...
Journal of structural biology 184 (2), 182-192, 2013
482013
Synthesis, Structure–Activity Relationships, and In Vivo Evaluation of Novel Tetrahydropyran-Based Thiodisaccharide Mimics as Galectin-3 Inhibitors
L Xu, RA Hartz, BR Beno, K Ghosh, JK Shukla, A Kumar, D Patel, ...
Journal of Medicinal Chemistry, 2021
182021
Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders
H Lu, L Kopcho, K Ghosh, M Witmer, M Parker, S Gupta, M Paul, ...
Analytical biochemistry 501, 56-65, 2016
172016
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase
KJ Eastman, K Parcella, KS Yeung, KA Grant-Young, J Zhu, T Wang, ...
MedChemComm 8 (4), 796-806, 2017
152017
A comparative three-dimensional model of the carboxy-terminal domain of the lambda repressor and its use to build intact repressor tetramer models bound to adjacent operator sites
R Chattopadhyaya, K Ghosh
Journal of structural biology 141 (2), 103-114, 2003
102003
pH-dependent autocleavage of lambda repressor occurs in the operator-bound form: characterization of lambda repressor autocleavage
K Ghosh, PAL Atasi, R Chattopadhyaya
Biochemical Journal 379 (2), 325-330, 2004
92004
Characterization of recombinantly expressed rat and monkey intestinal alkaline phosphatases: in vitro studies and in vivo correlations
M Subramanian, S Paruchury, S Singh, SP Singh, R Arla, S Pahwa, ...
Drug Metabolism and Disposition, dmd. 113.051987, 2013
72013
Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney (HEK293) cell based mammalian system
S Selvakumar, P Bhutani, K Ghosh, P Krishnamurthy, S Kallipatti, ...
Drug Metabolism and Disposition, dmd. 113.055491, 2013
62013
Papain does not cleave operator-bound lambda repressor: Structural characterization of the carboxy terminal domain and the hinge
K Ghosh, R Chattopadhyaya
Journal of Biomolecular Structure and Dynamics 18 (4), 557-567, 2001
42001
The mechanism of asymmetric strand exchange in Cre-loxP site-specific recombination
G Van Duyne, K Ghosh
The FASEB Journal 21 (5), A44-A44, 2007
12007
A structural model for the Cre-loxP site-specific recombination pathway
GD Van Duyne, F Guo, D Gopaul, K Ghosh
Faseb Journal 15 (5), A1155-A1155, 2001
12001
Discovery of BMS-986160 as a second-generation inhibitor of the hepatitis C virus NS3/4A with pan-genotypic antiviral activity
LQ Sun, E Mull, S Kandhasamy, VR Baratam, S Puttaswamy, N Pulicharla, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 258, 2019
2019
Second-generation inhibitors of the hepatitis C virus NS3/4A protease: Discovery of BMS-986144 with pan-genotypic antiviral activity
LQ Sun, E Mull, Q Zhao, E Gillis, M Bowsher, S D'Andrea, Z Zheng, ...
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 254, 2017
2017
EXPRESSION AND CHARACTERIZATION OF CYNOMOLGUS CYTOCHROME P450 3A4
M Subramanian, P Bhutani, S Selvakumar, K Ghosh, P Krishnamurthy, ...
DRUG METABOLISM REVIEWS 45, 89-89, 2014
2014
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