| Action potential generation requires a high sodium channel density in the axon initial segment MHP Kole, SU Ilschner, BM Kampa, SR Williams, PC Ruben, GJ Stuart Nature neuroscience 11 (2), 178-186, 2008 | 719 | 2008 |
| Voltage sensors in domains III and IV, but not I and II, are immobilized by Na+ channel fast inactivation A Cha, PC Ruben, AL George, E Fujimoto, F Bezanilla Neuron 22 (1), 73-87, 1999 | 317 | 1999 |
| Exome sequencing and the management of neurometabolic disorders M Tarailo-Graovac, C Shyr, CJ Ross, GA Horvath, R Salvarinova, XC Ye, ... New England Journal of Medicine 374 (23), 2246-2255, 2016 | 313 | 2016 |
| Evolutionary diversification of TTX-resistant sodium channels in a predator–prey interaction SL Geffeney, E Fujimoto, ED Brodie III, ED Brodie Jr, PC Ruben Nature 434 (7034), 759-763, 2005 | 260 | 2005 |
| Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels S Geffeney, ED Brodie Jr, PC Ruben, ED Brodie III Science 297 (5585), 1336-1339, 2002 | 220 | 2002 |
| Slow inactivation in voltage-gated sodium channels: molecular substrates and contributions to channelopathies YY Vilin, PC Ruben Cell biochemistry and biophysics 35, 171-190, 2001 | 217 | 2001 |
| Interaction between voltage-gated sodium channels and the neurotoxin, tetrodotoxin CH Lee, PC Ruben Channels 2 (6), 407-412, 2008 | 210 | 2008 |
| Inhibitory effects of cannabidiol on voltage-dependent sodium currents MR Ghovanloo, NG Shuart, J Mezeyova, RA Dean, PC Ruben, ... Journal of Biological Chemistry 293 (43), 16546-16558, 2018 | 172 | 2018 |
| Interaction between fast and slow inactivation in Skm1 sodium channels DE Featherstone, JE Richmond, PC Ruben Biophysical journal 71 (6), 3098-3109, 1996 | 154 | 1996 |
| Slow inactivation in human cardiac sodium channels JE Richmond, DE Featherstone, HA Hartmann, PC Ruben Biophysical journal 74 (6), 2945-2952, 1998 | 119 | 1998 |
| Loss-of-function mutations in SCN4A cause severe foetal hypokinesia or ‘classical’ congenital myopathy IT Zaharieva, MG Thor, EC Oates, C Van Karnebeek, G Hendson, E Blom, ... Brain 139 (3), 674-691, 2016 | 117 | 2016 |
| Structural determinants of slow inactivation in human cardiac and skeletal muscle sodium channels YY Vilin, N Makita, AL George, PC Ruben Biophysical journal 77 (3), 1384-1393, 1999 | 102 | 1999 |
| A defect in skeletal muscle sodium channel deactivation exacerbates hyperexcitability in human paramyotonia congenita DE Featherstone, E Fujimoto, PC Ruben The Journal of physiology 506 (3), 627-638, 1998 | 79 | 1998 |
| A single residue differentiates between human cardiac and skeletal muscle Na+ channel slow inactivation YY Vilin, E Fujimoto, PC Ruben Biophysical Journal 80 (5), 2221-2230, 2001 | 77 | 2001 |
| Steady-state availability of sodium channels. Interactions between activation and slow inactivation PC Ruben, JG Starkus, MD Rayner Biophysical journal 61 (4), 941-955, 1992 | 77 | 1992 |
| Analysis of FMRF-amide effects on Aplysia bursting neurons P Ruben, JW Johnson, S Thompson Journal of neuroscience 6 (1), 252-259, 1986 | 77 | 1986 |
| Voltage gated sodium channels in cancer and their potential mechanisms of action M Angus, P Ruben Channels 13 (1), 400-409, 2019 | 59 | 2019 |
| Voltage-sensitive and solvent-sensitive processes in ion channel gating. Kinetic effects of hyperosmolar media on activation and deactivation of sodium channels MD Rayner, JG Starkus, PC Ruben, DA Alicata Biophysical journal 61 (1), 96-108, 1992 | 55 | 1992 |
| Crustacean peptidergic neurons in culture show immediate outgrowth in simple medium. I Cooke, R Graf, S Grau, B Haylett, D Meyers, P Ruben Proceedings of the National Academy of Sciences 86 (1), 402-406, 1989 | 53 | 1989 |
| Cannabidiol interactions with voltage-gated sodium channels LG Sait, A Sula, MR Ghovanloo, D Hollingworth, PC Ruben, BA Wallace Elife 9, e58593, 2020 | 52 | 2020 |
Alfred L. George, Jr.Professor and Chair of Pharmacology, Northwestern UniversityVerified email at northwestern.edu
