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Manuel M. Paz
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Polyhomologation. A living polymethylene synthesis
KJ Shea, JW Walker, H Zhu, M Paz, J Greaves
Journal of the American Chemical Society 119 (38), 9049-9050, 1997
1661997
A new mechanism of action for the anticancer drug mitomycin C: mechanism-based inhibition of thioredoxin reductase
MM Paz, X Zhang, J Lu, A Holmgren
Chemical research in toxicology 25 (7), 1502-1511, 2012
1342012
The boron-catalyzed polymerization of dimethylsulfoxonium methylide. A living polymethylene synthesis
BB Busch, MM Paz, KJ Shea, CL Staiger, JM Stoddard, JR Walker, ...
Journal of the American Chemical Society 124 (14), 3636-3646, 2002
1212002
Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C
Y Palom, G Suresh Kumar, LQ Tang, MM Paz, SM Musser, S Rockwell, ...
Chemical research in toxicology 15 (11), 1398-1406, 2002
1162002
Polyhomologation: Synthesis of novel polymethylene architectures by a living polymerization of dimethylsulfoxonium methylide
KJ Shea, BB Busch, MM Paz
Angewandte Chemie International Edition 37 (10), 1391-1393, 1998
941998
On the stereoselectivity of the reaction of N-(9-Phenylfluoren-9-yl) aspartate Enolates with electrophiles. Synthesis of enantiomerically pure 3-hydroxy-, 3-amino-, and 3 …
E Fernandez-Megia, MM Paz, FJ Sardina
The Journal of Organic Chemistry 59 (25), 7643-7652, 1994
631994
Mitomycin dimers: polyfunctional cross-linkers of DNA
MM Paz, G Suresh Kumar, M Glover, MJ Waring, M Tomasz
Journal of Medicinal Chemistry 47 (12), 3308-3319, 2004
592004
DNA− DNA Interstrand Cross-Linking by FR66979: Intermediates in the Activation Cascade
MM Paz, PB Hopkins
Journal of the American Chemical Society 119 (26), 5999-6005, 1997
571997
Enantiomerically pure dimethyl (2S)-N-(9-phenylfluoren-9-yl)-3, 4-didehydroglutamate as chiral educt. Chirospecific synthesis of (+)-5-O-carbamoylpolyoxamic acid and 3 …
MM Paz, FJ Sardina
The Journal of Organic Chemistry 58 (25), 6990-6995, 1993
541993
Mitomycin C linked to DNA minor groove binding agents: synthesis, reductive activation, DNA binding and cross-linking properties and in vitro antitumor activity
MM Paz, A Das, M Tomasz
Bioorganic & medicinal chemistry 7 (12), 2713-2726, 1999
521999
Selective activation of mitomycin a by thiols to form DNA Cross-links and monoadducts: Biochemical basis for the modulation of mitomycin cytotoxicity by the quinone redox potential
MM Paz, A Das, Y Palom, QY He, M Tomasz
Journal of medicinal chemistry 44 (17), 2834-2842, 2001
462001
Reductive activation of mitomycin C by thiols: kinetics, mechanism, and biological implications
MM Paz
Chemical research in toxicology 22 (10), 1663-1668, 2009
402009
Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/electrospray tandem mass spectrometry
MM Paz, S Ladwa, E Champeil, Y Liu, S Rockwell, EK Boamah, ...
Chemical research in toxicology 21 (12), 2370-2378, 2008
392008
DNA-DNA interstrand cross-linking by FR66979 and FR900482: Requirement of metal ions during reductive activation
MM Paz, PB Hopkins
Tetrahedron letters 38 (3), 343-346, 1997
381997
Solution Structure of a Guanine-N7-Linked Complex of the Mitomycin C Metabolite 2,7-Diaminomitosene and DNA. Basis of Sequence Selectivity,
G Subramaniam, MM Paz, G Suresh Kumar, A Das, Y Palom, CC Clement, ...
Biochemistry 40 (35), 10473-10484, 2001
282001
A stereodivergent chirospecific synthesis of (3R) and (3S) 3-hydroxyaspartates by hydroxylation of aspartate diester enolates
FJ Sardina, MM Paz, E Fernández-Megía, RF de Boer, MP Alvarez
Tetrahedron letters 33 (32), 4637-4640, 1992
241992
Reductive activation of mitomycin A by thiols
MM Paz, M Tomasz
Organic Letters 3 (18), 2789-2792, 2001
222001
Synthesis of an Oligodeoxyribonucleotide Adduct of Mitomycin C by the Postoligomerization Method via a Triamino Mitosene
E Champeil, MM Paz, S Ladwa, CC Clement, A Zatorski, M Tomasz
Journal of the American Chemical Society 130 (29), 9556-9565, 2008
212008
Size-dependent transport and cytotoxicity of mitomycin-gold nanoparticle conjugates in 2D and 3D mammalian cell models
I García, M Henriksen-Lacey, J Calvo, DJ de Aberasturi, MM Paz, ...
Bioconjugate chemistry 30 (1), 242-252, 2018
202018
The molecular toxicology of mitomycin C
MM Paz, CA Pritsos
Advances in Molecular Toxicology 6, 243-299, 2012
192012
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