| Brigatinib, an anaplastic lymphoma kinase inhibitor, abrogates activity and growth in ALK-positive neuroblastoma cells, Drosophila and mice JT Siaw, H Wan, K Pfeifer, VM Rivera, J Guan, RH Palmer, B Hallberg Oncotarget 7 (20), 29011, 2016 | 61 | 2016 |
| Clinical response of the novel activating ALK-I1171T mutation in neuroblastoma to the ALK inhibitor ceritinib J Guan, S Fransson, JT Siaw, D Treis, J Van den Eynden, D Chand, ... Molecular Case Studies 4 (4), a002550, 2018 | 56 | 2018 |
| 11q deletion or ALK activity curbs DLG2 expression to maintain an undifferentiated state in neuroblastoma JT Siaw, N Javanmardi, J Van den Eynden, DE Lind, S Fransson, ... Cell reports 32 (12), 2020 | 34 | 2020 |
| ATR inhibition enables complete tumour regression in ALK-driven NB mouse models J Szydzik, DE Lind, B Arefin, Y Kurhe, G Umapathy, JT Siaw, A Claeys, ... Nature communications 12 (1), 6813, 2021 | 25 | 2021 |
| Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent J Guan, G Wolfstetter, J Siaw, D Chand, F Hugosson, RH Palmer, ... Oncotarget 8 (7), 11566, 2017 | 21 | 2017 |
| BioID-screening identifies PEAK1 and SHP2 as components of the ALK proximitome in neuroblastoma cells E Uckun, JT Siaw, J Guan, V Anthonydhason, J Fuchs, G Wolfstetter, ... Journal of Molecular Biology 433 (19), 167158, 2021 | 14 | 2021 |
| Sustained response to entrectinib in an infant with a germline ALKAL2 variant and refractory metastatic neuroblastoma with chromosomal 2p gain and anaplastic lymphoma kinase … D Treis, G Umapathy, S Fransson, J Guan, P Mendoza-García, JT Siaw, ... JCO precision oncology 6, e2100271, 2022 | 12 | 2022 |
| Loss of ret promotes mesenchymal identity in neuroblastoma cells JT Siaw, JL Gabre, E Uçkun, M Vigny, W Zhang, J Van den Eynden, ... Cancers 13 (8), 1909, 2021 | 9 | 2021 |
| A clinically annotated post-mortem approach to study multi-organ somatic mutational clonality in normal tissues T Luijts, K Elliott, JT Siaw, J Van de Velde, E Beyls, A Claeys, T Lammens, ... Scientific Reports 12 (1), 10322, 2022 | 3 | 2022 |
| Anaplastic lymphoma kinase activity, a therapeutic target, suppresses neuroblastoma cell differentiation JT Siaw | | 2020 |
