Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II S Larochelle, R Amat, K Glover-Cutter, M Sansó, C Zhang, JJ Allen, ... Nature structural & molecular biology 19 (11), 1108-1115, 2012 | 374 | 2012 |
SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) gene in skeletal muscle through the PGC-1α autoregulatory loop and … R Amat, A Planavila, SL Chen, R Iglesias, M Giralt, F Villarroya Journal of Biological Chemistry 284 (33), 21872-21880, 2009 | 255 | 2009 |
The N-terminal phosphorylation of RB by p38 bypasses its inactivation by CDKs and prevents proliferation in cancer cells A Gubern, M Joaquin, M Marquès, P Maseres, J Garcia-Garcia, R Amat, ... Molecular cell 64 (1), 25-36, 2016 | 97 | 2016 |
SIRT1 is involved in glucocorticoid-mediated control of uncoupling protein-3 gene transcription R Amat, G Solanes, M Giralt, F Villarroya Journal of Biological Chemistry 282 (47), 34066-34076, 2007 | 95 | 2007 |
Chemical genetics reveals a specific requirement for Cdk2 activity in the DNA damage response and identifies Nbs1 as a Cdk2 substrate in human cells L Wohlbold, KA Merrick, S De, R Amat, JH Kim, S Larochelle, JJ Allen, ... Public Library of Science 8 (8), e1002935, 2012 | 81 | 2012 |
Activation of the p53 transcriptional program sensitizes cancer cells to Cdk7 inhibitors S Kalan, R Amat, MM Schachter, N Kwiatkowski, BJ Abraham, Y Liang, ... Cell reports 21 (2), 467-481, 2017 | 74 | 2017 |
Differential 3, 5, 3′-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of fatty acids P de Lange, A Feola, M Ragni, R Senese, M Moreno, A Lombardi, ... Endocrinology 148 (8), 4064-4072, 2007 | 56 | 2007 |
Rapid reversible changes in compartments and local chromatin organization revealed by hyperosmotic shock R Amat, R Böttcher, F Le Dily, E Vidal, J Quilez, Y Cuartero, M Beato, ... Genome research 29 (1), 18-28, 2019 | 50 | 2019 |
Molecular profiling of long‐term responders to immune checkpoint inhibitors in advanced non‐small cell lung cancer J Frigola, A Navarro, C Carbonell, A Callejo, P Iranzo, S Cedrés, ... Molecular oncology 15 (4), 887-900, 2021 | 30 | 2021 |
RARγ is required for correct deposition and removal of Suz12 and H2A. Z in embryonic stem cells R Amat, LJ Gudas Journal of cellular physiology 226 (2), 293-298, 2011 | 30 | 2011 |
Overview of checkpoint inhibitors mechanism of action. Role of immune-related adverse events and their treatment on progression of underlying cancer P Iranzo, A Callejo, JD Assaf, G Molina, DE Lopez, D Garcia-Illescas, ... Frontiers in Medicine, 1488, 2022 | 28 | 2022 |
LRRC8A-containing chloride channel is crucial for cell volume recovery and survival under hypertonic conditions SA Serra, P Stojakovic, R Amat, F Rubio-Moscardo, P Latorre, ... Proceedings of the National Academy of Sciences 118 (23), e2025013118, 2021 | 27 | 2021 |
Interrelations between patients’ clinicopathological characteristics and their association with response to immunotherapy in a real-world cohort of NSCLC patients A Callejo, J Frigola, P Iranzo, C Carbonell, N Diaz, D Marmolejo, JD Assaf, ... Cancers 13 (13), 3249, 2021 | 11 | 2021 |
Efficacy of chemotherapy for malignant pleural mesothelioma according to histology in a real-world cohort S Cedres, JD Assaf, P Iranzo, A Callejo, N Pardo, A Navarro, ... Scientific Reports 11 (1), 21357, 2021 | 10 | 2021 |
PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells F Exposito, M Redrado, M Houry, K Hastings, M Molero-Abraham, ... Cancer Research 83 (15), 2513-2526, 2023 | 6 | 2023 |
DSTYK inhibition increases the sensitivity of lung cancer cells to T cell–mediated cytotoxicity K Valencia, M Echepare, Á Teijeira, A Pasquier, C Bértolo, C Sainz, ... Journal of Experimental Medicine 219 (12), e20220726, 2022 | 6 | 2022 |
High levels of chromosomal aberrations negatively associate with benefit to checkpoint inhibition in NSCLC J Frigola, C Carbonell, P Iranzo, N Pardo, A Callejo, S Cedres, ... Journal for immunotherapy of cancer 10 (4), 2022 | 5 | 2022 |
The EU-funded I3LUNG Project: integrative science, intelligent data platform for individualized LUNG cancer care with immunotherapy A Prelaj, M Ganzinelli, LC Roisman, ALG Pedrocchi, S Kosta, M Restelli, ... Clinical Lung Cancer 24 (4), 381-387, 2023 | 3 | 2023 |
P465L‐PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates S Rodriguez‐Cuenca, S Carobbio, G Barceló‐Coblijn, X Prieur, J Relat, ... Diabetes, Obesity and Metabolism 20 (10), 2339-2350, 2018 | 3 | 2018 |
PTEN loss confers resistance to anti-PD-1 therapy in NSCLC by increasing tumor infiltration of T regulatory cells F Exposito, M Redrado, M Houry, K Hastings, M Molero-Abraham, ... Cancer Research 83 (7_Supplement), 1124-1124, 2023 | 2 | 2023 |