Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications YS Wang, S Youngster, M Grace, J Bausch, R Bordens, DF Wyss Advanced drug delivery reviews 54 (4), 547-570, 2002 | 593 | 2002 |
Conformation and function of the N-linked glycan in the adhesion domain of human CD2 DF Wyss, JS Choi, J Li, MH Knoppers, KJ Willis, ARN Arulanandam, ... Science 269 (5228), 1273-1278, 1995 | 413 | 1995 |
An orally available non-nucleotide STING agonist with antitumor activity BS Pan, SA Perera, JA Piesvaux, JP Presland, GK Schroeder, ... Science 369 (6506), eaba6098, 2020 | 340 | 2020 |
Template-assembled synthetic proteins with four-helix-bundle topology. Total chemical synthesis and conformational studies M Mutter, GG Tuchscherer, C Miller, KH Altmann, RI Carey, DF Wyss, ... Journal of the American Chemical Society 114 (4), 1463-1470, 1992 | 257 | 1992 |
The structural role of sugars in glycoproteins DF Wyss, G Wagner Current opinion in biotechnology 7 (4), 409-416, 1996 | 230 | 1996 |
Identification of the major positional isomer of pegylated interferon alpha-2b YS Wang, S Youngster, J Bausch, R Zhang, C McNemar, DF Wyss Biochemistry 39 (35), 10634-10640, 2000 | 191 | 2000 |
Competition STD NMR for the detection of high‐affinity ligands and NMR‐based screening YS Wang, D Liu, DF Wyss Magnetic Resonance in Chemistry 42 (6), 485-489, 2004 | 182 | 2004 |
Discovery of cyclic acylguanidines as highly potent and selective β-site amyloid cleaving enzyme (BACE) inhibitors: Part I Inhibitor design and validation Z Zhu, ZY Sun, Y Ye, J Voigt, C Strickland, EM Smith, J Cumming, L Wang, ... Journal of medicinal chemistry 53 (3), 951-965, 2010 | 165 | 2010 |
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel μM leads for the development … YS Wang, C Strickland, JH Voigt, ME Kennedy, BM Beyer, MM Senior, ... Journal of medicinal chemistry 53 (3), 942-950, 2010 | 156 | 2010 |
Structure, biology, and therapeutic implications of pegylated interferon alpha-2b S Youngster, YS Wang, M Grace, J Bausch, R Bordens, DF Wyss Current pharmaceutical design 8 (24), 2139-2157, 2002 | 133 | 2002 |
The CD58 (LFA-3) binding site is a localized and highly charged surface area on the AGFCC'C" face of the human CD2 adhesion domain. AR Arulanandam, JM Withka, DF Wyss, G Wagner, A Kister, P Pallai, ... Proceedings of the National Academy of Sciences 90 (24), 11613-11617, 1993 | 125 | 1993 |
Flexible lid to the p53-binding domain of human Mdm2: implications for p53 regulation MA McCoy, JJ Gesell, MM Senior, DF Wyss Proceedings of the National Academy of Sciences 100 (4), 1645-1648, 2003 | 115 | 2003 |
Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor BJ Hare, DF Wyss, MS Osburne, PS Kern, EL Reinherz, G Wagner Nature structural biology 6 (6), 574-581, 1999 | 112 | 1999 |
Spatial localization of ligand binding sites from electron current density surfaces calculated from NMR chemical shift perturbations MA McCoy, DF Wyss Journal of the American Chemical Society 124 (39), 11758-11763, 2002 | 105 | 2002 |
ANANTIN-A PEPTIDE ANTAGONIST OF THE ATRIAL NATRIURETIC FACTOR (ANF) II. DETERMINATION OF THE PRIMARY SEQUENCE BY NMR ON THE BASIS OF PROTON ASSIGNMENTS DF Wyss, HW Lahm, M Manneberg, AM Labhardt The Journal of antibiotics 44 (2), 172-180, 1991 | 90 | 1991 |
Structure of the glycosylated adhesion domain of human T lymphocyte glycoprotein CD2 JM Withka, DF Wyss, G Wagner, ARN Arulanandam, EL Reinherz, ... Structure 1 (1), 69-81, 1993 | 80 | 1993 |
Structures of protein− protein complexes are docked using only nmr restraints from residual dipolar coupling and chemical shift perturbations MA McCoy, DF Wyss Journal of the American Chemical Society 124 (10), 2104-2105, 2002 | 78 | 2002 |
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors DF Wyss, YS Wang, HL Eaton, C Strickland, JH Voigt, Z Zhu, AW Stamford Fragment-based drug discovery and X-ray crystallography, 83-114, 2012 | 74 | 2012 |
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening DF Wyss, A Arasappan, MM Senior, YS Wang, BM Beyer, FG Njoroge, ... Journal of medicinal chemistry 47 (10), 2486-2498, 2004 | 71 | 2004 |
Alignment of weakly interacting molecules to protein surfaces using simulations of chemical shift perturbations MA McCoy, DF Wyss Journal of Biomolecular NMR 18, 189-198, 2000 | 71 | 2000 |