| Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain–like mechanism PK Mattila, A Pykalainen, J Saarikangas, VO Paavilainen, H Vihinen, ... The Journal of cell biology 176 (7), 953-964, 2007 | 455 | 2007 |
| Prolonged and tunable residence time using reversible covalent kinase inhibitors JM Bradshaw, JM McFarland, VO Paavilainen, A Bisconte, D Tam, ... Nature chemical biology 11 (7), 525-531, 2015 | 410 | 2015 |
| Regulation of cytoskeletal dynamics by actin-monomer-binding proteins VO Paavilainen, E Bertling, S Falck, P Lappalainen Trends in cell biology 14 (7), 386-394, 2004 | 344 | 2004 |
| Electrophilic fragment-based design of reversible covalent kinase inhibitors RM Miller, VO Paavilainen, S Krishnan, IM Serafimova, J Taunton Journal of the American Chemical Society 135 (14), 5298-5301, 2013 | 211 | 2013 |
| Structure of the actin-depolymerizing factor homology domain in complex with actin VO Paavilainen, E Oksanen, A Goldman, P Lappalainen The Journal of cell biology 182 (1), 51-59, 2008 | 177 | 2008 |
| GMF is a cofilin homolog that binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation M Gandhi, BA Smith, M Bovellan, V Paavilainen, K Daugherty-Clarke, ... Current biology 20 (9), 861-867, 2010 | 134 | 2010 |
| Identification of yeast cofilin residues specific for actin monomer and PIP2 binding PJ Ojala, V Paavilainen, P Lappalainen Biochemistry 40 (51), 15562-15569, 2001 | 117 | 2001 |
| Mycolactone subverts immunity by selectively blocking the Sec61 translocon L Baron, AO Paatero, JD Morel, F Impens, L Guenin-Macé, S Saint-Auret, ... Journal of Experimental Medicine 213 (13), 2885-2896, 2016 | 109 | 2016 |
| Biological role and structural mechanism of twinfilin–capping protein interaction S Falck, VO Paavilainen, MA Wear, JG Grossmann, JA Cooper, ... The EMBO journal 23 (15), 3010-3019, 2004 | 98 | 2004 |
| The two ADF-H domains of twinfilin play functionally distinct roles in interactions with actin monomers PJ Ojala, VO Paavilainen, MK Vartiainen, R Tuma, AG Weeds, ... Molecular biology of the cell 13 (11), 3811-3821, 2002 | 98 | 2002 |
| Apratoxin kills cells by direct blockade of the Sec61 protein translocation channel AO Paatero, J Kellosalo, BM Dunyak, J Almaliti, JE Gestwicki, ... Cell chemical biology 23 (5), 561-566, 2016 | 91 | 2016 |
| Structural basis and evolutionary origin of actin filament capping by twinfilin VO Paavilainen, M Hellman, E Helfer, M Bovellan, A Annila, MF Carlier, ... Proceedings of the National Academy of Sciences 104 (9), 3113-3118, 2007 | 88 | 2007 |
| An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate AL MacKinnon, VO Paavilainen, A Sharma, RS Hegde, J Taunton Elife 3, e01483, 2014 | 84 | 2014 |
| Rapamycin-inspired macrocycles with new target specificity Z Guo, SY Hong, J Wang, S Rehan, W Liu, H Peng, M Das, W Li, S Bhat, ... Nature chemistry 11 (3), 254-263, 2019 | 81 | 2019 |
| Ipomoeassin F binds Sec61α to inhibit protein translocation G Zong, Z Hu, S O’keefe, D Tranter, MJ Iannotti, L Baron, B Hall, ... Journal of the American Chemical Society 141 (21), 8450-8461, 2019 | 64 | 2019 |
| Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin VO Paavilainen, MC Merckel, S Falck, PJ Ojala, E Pohl, M Wilmanns, ... Journal of Biological Chemistry 277 (45), 43089-43095, 2002 | 59 | 2002 |
| Proteomics reveals scope of mycolactone-mediated Sec61 blockade and distinctive stress signature JD Morel, AO Paatero, J Wei, JW Yewdell, L Guenin-Macé, D Van Haver, ... Molecular & Cellular Proteomics 17 (9), 1750-1765, 2018 | 52 | 2018 |
| Functional reconstitution of human equilibrative nucleoside transporter-1 into styrene maleic acid co-polymer lipid particles S Rehan, VO Paavilainen, VP Jaakola Biochimica et Biophysica Acta (BBA)-Biomembranes 1859 (5), 1059-1065, 2017 | 41 | 2017 |
| Coibamide A targets Sec61 to prevent biogenesis of secretory and membrane proteins D Tranter, AO Paatero, S Kawaguchi, S Kazemi, JD Serrill, J Kellosalo, ... ACS Chemical Biology 15 (8), 2125-2136, 2020 | 39 | 2020 |
| Solution structure of coactosin reveals structural homology to ADF/cofilin family proteins M Hellman, VO Paavilainen, P Naumanen, P Lappalainen, A Annila, ... FEBS letters 576 (1-2), 91-96, 2004 | 35 | 2004 |
