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Juan Carlos Lacal (ORCID: 0000-0002-1908-2777)
Juan Carlos Lacal (ORCID: 0000-0002-1908-2777)
Profesor de Investigación. Instituto de Investigaciones Biomédicas CSIC
Verified email at iib.uam.es
Title
Cited by
Cited by
Year
Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.
R Perona, S Montaner, L Saniger, I Sanchez-Perez, R Bravo, JC Lacal
Genes & development 11 (4), 463-475, 1997
7911997
Overexpression of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal human cancers
AR de Molina, A Rodrı́guez-González, R Gutiérrez, L Martınez-Pineiro, ...
Biochemical and biophysical research communications 296 (3), 580-583, 2002
4202002
Rho signals to cell growth and apoptosis
S Aznar, JC Lacal
Cancer letters 165 (1), 1-10, 2001
4042001
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene
JC Lacal, J Moscat, SA Aaronson
Nature 330 (6145), 269-272, 1987
3541987
Rho GTPase expression in tumourigenesis: evidence for a significant link
TG Del Pulgar, SA Benitah, PF Valerón, C Espina, JC Lacal
Bioessays 27 (6), 602-613, 2005
3182005
Multiple signalling pathways lead to the activation of the nuclear factor κB by the Rho family of GTPases
S Montaner, R Perona, L Saniger, JC Lacal
Journal of Biological Chemistry 273 (21), 12779-12785, 1998
2961998
Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy
A Ramírez de Molina, R Gutiérrez, MA Ramos, JM Silva, J Silva, F Bonilla, ...
Oncogene 21 (27), 4317-4322, 2002
2922002
Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites
MV Céspedes, C Espina, MA García-Cabezas, M Trias, A Boluda, ...
The American journal of pathology 170 (3), 1077-1085, 2007
2222007
Phosphorylcholine: a novel second messenger essential for mitogenic activity of growth factors.
A Cuadrado, A Carnero, F Dolfi, B Jiménez, JC Lacal
Oncogene 8 (11), 2959-2968, 1993
2211993
Rho proteins induce metastatic properties in vivo
L Peso, R Hernández-Alcoceba, N Embade, A Carnero, P Esteve, C Paje, ...
Oncogene 15 (25), 3047-3057, 1997
2171997
Choline kinase inhibitors as a novel approach for antiproliferative drug design
R Hernández-Alcoceba, L Saniger, J Campos, MC Núñez, F Khaless, ...
Oncogene 15 (19), 2289-2301, 1997
2071997
Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation
SA Benitah, PF Valerón, L Van Aelst, CJ Marshall, JC Lacal
Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1705 (2), 121-132, 2004
1972004
A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.
EG Lapetina, JC Lacal, BR Reep, L Molina y Vedia
Proceedings of the National Academy of Sciences 86 (9), 3131-3134, 1989
1931989
Expression of choline kinase alpha to predict outcome in patients with early-stage non-small-cell lung cancer: a retrospective study
AR de Molina, J Sarmentero-Estrada, C Belda-Iniesta, M Tarón, ...
The lancet oncology 8 (10), 889-897, 2007
1792007
In Vivo Antitumor Activity of Choline Kinase Inhibitors: A Novel Target for Anticancer Drug Discovery
R Hernández-Alcoceba, F Fernández, JC Lacal
Cancer research 59 (13), 3112-3118, 1999
1791999
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of the choline kinase inhibitor MN58b in human carcinoma models
NMS Al-Saffar, H Troy, AR de Molina, LE Jackson, B Madhu, JR Griffiths, ...
Cancer research 66 (1), 427-434, 2006
1712006
Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression
AR de Molina, M Bánez-Coronel, R Gutiérrez, A Rodríguez-González, ...
Cancer research 64 (18), 6732-6739, 2004
1682004
Choline uptake and metabolism modulate macrophage IL-1β and IL-18 production
E Sanchez-Lopez, Z Zhong, A Stubelius, SR Sweeney, LM Booshehri, ...
Cell metabolism 29 (6), 1350-1362. e7, 2019
1622019
Tumorigenic activity of rho genes from Aplysia californica.
R Perona, P Esteve, B Jimenez, RP Ballestero, JC Lacal
Oncogene 8 (5), 1285-1292, 1993
1601993
Rho GTPases: potential candidates for anticancer therapy
S Aznar, P Fernández-Valerón, C Espina, JC Lacal
Cancer letters 206 (2), 181-191, 2004
1572004
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