The ubiquitin system regulates virtually all aspects of cellular function. We report a method
to target the myriad enzymes that govern ubiquitination of protein substrates. We used …

… Avinash D Persaud is Chairman of two London-based investment houses: Intelligence
Capital Limited specializes in structuring finance for large projects and Elara Capital Limited …

HECT-family E3 ligases ubiquitinate protein substrates to control virtually every eukaryotic
process and are misregulated in numerous diseases. Nonetheless, understanding of HECT …

Ligand binding to the receptor tyrosine kinase fibroblast growth factor (FGF) receptor 1 (FGFR1)
causes dimerization and activation by transphosphorylation of tyrosine residues in the …

Fibroblast growth factor receptor 1 (FGFR1) has critical roles in cellular proliferation and
differentiation during animal development and adult homeostasis. Here, we show that human …

Renal tubular epithelial cells (RTECs) perform the essential function of maintaining the
constancy of body fluid composition and volume. Toxic, inflammatory, or hypoxic-insults to …

mTORC1 regulates cellular growth and is activated by growth factors and by essential amino
acids such as Leu. Leu enters cells via the Leu transporter LAT1-4F2hc (LAT1). Here we …

Ubiquitylation controls protein function and degradation. Therefore, ubiquitin ligases need
to be tightly controlled. We discovered an evolutionarily conserved allosteric restraint …

This paper discusses a "pure" form of financial contagion, unrelated to economic fundamentals
- investors' shifting appetite for risk. It provides an analytical framework for identifying …

Autologous stem cell transplant (ASCT) with high‐dose melphalan (HDM) is the standard
treatment for fit multiple myeloma (MM) patients. It is generally believed that some DNA repair …