Although the neurobiology of autism has been studied for more than two decades, the majority
of these studies have examined brain structure 10, 20, or more years after the onset of …

Although it has long been thought that frontal lobe abnormality must play an important part in
generating the severe impairment in higher-order social, emotional and cognitive functions …

The broad variation in phenotypes and severities within autism spectrum disorders suggests
the involvement of multiple predisposing factors, interacting in complex ways with normal …

It has been long debated whether averaged electrical responses recorded from the scalp
result from stimulus-evoked brain events or stimulus-induced changes in ongoing brain …

Over the past few decades, neuroimaging has become a ubiquitous tool in basic research
and clinical studies of the human brain. However, no reference standards currently exist to …

ContextAutism most commonly appears by 2 to 3 years of life, at which time the brain is
already abnormally large. This raises the possibility that brain overgrowth begins much earlier, …

Context Autism often involves early brain overgrowth, including the prefrontal cortex (PFC).
Although prefrontal abnormality has been theorized to underlie some autistic symptoms, the …

BACKGROUND: Multiple studies have reported increased brain size in autism, while others
have found no difference from normal. These conflicting results may be due to a lack of …

Background Autism involves early brain overgrowth and dysfunction, which is most strongly
evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons …

Several regions of the brain (including medial prefrontal cortex, rostral anterior cingulate,
posterior cingulate, and precuneus) are known to have high metabolic activity during rest, …