Evidence accumulated over more than two decades has implicated Ca2+ dysregulation in
brain aging and Alzheimer's disease (AD), giving rise to the Ca2+ hypothesis of brain aging …

Alzheimer disease (AD) is a progressive, neurodegenerative disorder that leads to
debilitating cognitive deficits. Although little is known about the early functional or …

Aggregation and deposition of β-amyloid and/or tau protein are the key neuropathological
features in neurodegenerative disorders such as Alzheimer's disease (AD) and other …

Sigma-2 receptor agonists have been shown to induce cell death via caspase-dependent
and caspase-independent pathways. Unfortunately, there is little information regarding the …

Memory processing requires tightly controlled signalling cascades, many of which are
dependent upon intracellular calcium (Ca 2+). Despite this, most work investigating calcium …

Stress to the endoplasmic reticulum (ER) is a recognized factor in Alzheimer's and
Parkinson's diseases, diabetes, heart disease, liver disorders and cancer. Thus, drugs that …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

The widely accepted oxidative stress theory of aging postulates that aging results from
accumulation of oxidative damage. A prediction of this theory is that, among species …

Spontaneous Ca 2+ events have been observed in diverse stem cell lines, including
carcinoma and mesenchymal stem cells. Interestingly, during cell cycle progression, cells …

Intracranial hypertension (IH) is a medical or surgical emergency that can be the common
ending of various neurological disorders, such as traumatic brain injury, cerebral vascular …