The basic features of DNA were elucidated during the half-century following the discovery of
the double helix. But it is only during the past decade that researchers have been able to …

It has been over 20 years since the pioneering work of Arthur Ashkin, and in the intervening
years, the field of optical tweezers has grown tremendously. Optical tweezers are now being …

… Michaelis & C. Bustamante, unpublished data). Measurements of V max and K M from the
ATP dependence of the velocity at various forces show that both decrease with opposing force …

… operated with a 20 mL min −1 flow of nitrogen and heating from 10 to 1000 C, at a rate of
10 C min −1 . The measurements were performed in triplicate, using (5.0 ± 0.2) mg of sample. …

The vast majority of coding variants are rare, and assessment of the contribution of rare
variants to complex traits is hampered by low statistical power and limited functional data. …

Genome-wide association studies (GWAS) have laid the foundation for investigations into the
biology of complex traits, drug development and clinical guidelines. However, the majority …

The rhesus macaque (Macaca mulatta) is an abundant primate species that diverged from
the ancestors of Homo sapiens about 25 million years ago. Because they are genetically and …

As a first step toward understanding how rare variants contribute to risk for complex diseases,
we sequenced 15,585 human protein-coding genes to an average median depth of 111× …

Understanding the genetic structure of human populations is of fundamental interest to
medical, forensic and anthropological sciences. Advances in high-throughput genotyping …

Asian rice, Oryza sativa is a cultivated, inbreeding species that feeds over half of the world's
population. Understanding the genetic basis of diverse physiological, developmental, and …