Action spectrum for melatonin regulation in humans: evidence for a novel circadian photoreceptor

GC Brainard, JP Hanifin, JM Greeson… - Journal of …, 2001 - Soc Neuroscience
… The aim of this study was to establish an action spectrum for light-induced melatonin
suppression that could help elucidate the ocular photoreceptor system for regulating the human …

[PDF][PDF] Light during darkness, melatonin suppression and cancer progression

…, RT Dauchy, LA Sauer, JA Krause, GC Brainard - Neuroendocrinology …, 2002 - nel.edu
Over the past few years, we have shown that the surge of melatonin in the circulation during
darkness represents a potent oncostatic signal to tissue-isolated rat hepatoma 7288CTC, …

[PDF][PDF] Ocular input for human melatonin regulation: relevance to breast cancer

G Glickman, R Levin, GC Brainard - Neuroendocrinology Letters, 2002 - instantdaylite.com
… exposure may be a risk factor for cancer is suggested by the suppressive effects of nocturnal
light on pineal melatonin [3,4] and the decrease in melatonin production that has been …

Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans

…, MD Rollag, JP Hanifin, GC Brainard - Journal of applied …, 2011 - journals.physiology.org
… blue LED light would have increased efficacy for melatonin suppression compared with the
… K white fluorescent light. To accomplish these aims, a within-subject study tested melatonin

High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light

SW Lockley, GC Brainard… - The Journal of clinical …, 2003 - academic.oup.com
… nm monochromatic light of equal photon density. Similarly, 460 nm monochromatic light
causes twice the amount of melatonin suppression compared to 555 nm monochromatic light, …

Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats

DE Blask, GC Brainard, RT Dauchy, JP Hanifin… - Cancer research, 2005 - AACR
light/dark cycle entrains circadian melatonin production to a 24-hour cycle, whereas ocular
exposure to light during darkness rapidly suppresses melatonin … of the light exposure (20, 21). …

[PDF][PDF] Dim light adaptation attenuates acute melatonin suppression in humans

…, MD Rollag, GC Brainard - Journal of biological …, 2006 - journals.sagepub.com
… SCN cell sensitivity to light stimuli, relative to various adaptive lighting conditions. These …
light adaptation will dampen the subsequent suppression of melatonin by monochromatic light

The spectral sensitivity of human circadian phase resetting and melatonin suppression to light changes dynamically with light duration

…, M Rüger, GC Brainard… - Proceedings of the …, 2022 - National Acad Sciences
light-induced suppression of melatonin overnight. We show that phase resetting and melatonin
… h) exposure to light but that, at the start of a light exposure, melatonin suppression is best …

[PDF][PDF] Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonin in humans

…, J Wang, H Cooper, GC Brainard - Journal of biological …, 2003 - journals.sagepub.com
light-induced suppression of melatonin. The aim of this study was to compare changes in
plasma melatonin levels when light … were exposed to patternless white light for 90 min between …

Short‐wavelength enrichment of polychromatic light enhances human melatonin suppression potency

GC Brainard, JP Hanifin, B Warfield… - Journal of pineal …, 2015 - Wiley Online Library
… In turn, the SCN transmit information about lighting and circadian time … melatonin is synthesized
8. As a result, daily patterns of light exposure entrain the circadian secretion of melatonin