Combination therapy with oseltamivir and favipiravir delays mortality but does not prevent oseltamivir resistance in immunodeficient mice infected with pandemic A …

M Baz, J Carbonneau, C Rhéaume, MH Cavanagh… - Viruses, 2018 - mdpi.com
… decrease morbidity and mortality in IS treated mice, we infected IS mice as described above
… Weight loss and mortality were monitored for 21 days. All placebo-treated infected IS mice

Oseltamivir treatment prevents the increased influenza virus disease severity and lethality occurring in chronic ethanol consuming mice

RA Langlois, DK Meyerholz… - Alcoholism: Clinical …, 2010 - Wiley Online Library
… Interestingly, despite these potential limitations, our results show that chronic EtOH exposed
mice treated with oseltamivir are protected from increased morbidity and mortality as well as …

Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1)

SG Zarogiannis, JW Noah, A Jurkuvenaite, C Steele… - Life sciences, 2012 - Elsevier
… of oseltamivir in terms of survival, lung viral load, injury to the alveolar-capillary barrier, and
inflammation in BALB/c mice after infection with mouse-… effective as oseltamivir in improving …

Treatment of oseltamivir-resistant influenza A (H1N1) virus infections in mice with antiviral agents

DF Smee, JG Julander, EB Tarbet, M Gross, J Nguyen - Antiviral research, 2012 - Elsevier
… The A/HK-H275Y model is also useful but we found that variable mortality occurred from
experiment to experiment (the studies presented here were acceptable, but other unreported …

Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice

DF Smee, DL Barnard, SM Jones - Antiviral Research, 2016 - Elsevier
… Against the H3N2 infection, there were insignificant decreases in mortality at the 2-mg/kg/day
dose compared to the H1N1pdm study. In addition, body weight losses in groups treated …

A pharmacologically immunosuppressed mouse model for assessing influenza B virus pathogenicity and oseltamivir treatment

BM Marathe, HH Mostafa, P Vogel, PNQ Pascua… - Antiviral research, 2017 - Elsevier
… morbidity and mortality in immunosuppressed mice, BR/08 … lethality in mice inoculated with
at least 10 3 TCID 50 /mouse. … mice, but the extent of pulmonary inflammation in these mice

Synergistic combinations of favipiravir and oseltamivir against wild-type pandemic and oseltamivir-resistant influenza A virus infections in mice

DF Smee, EB Tarbet, Y Furuta, JD Morrey… - Future …, 2013 - Taylor & Francis
… sometimes result in mortality. In these studies, we excluded two mice that died during the …
with these or related viruses with either oseltamivir or favipiravir monotherapy prior to these …

Combinations of oseltamivir and fibrates prolong the mean survival time of mice infected with the lethal H7N9 influenza virus

L Xu, L Bao, F Li, S Gu, Q Lv, J Yuan… - Journal of General …, 2015 - microbiologyresearch.org
… antiviral plus immunomodulator treatment still reduces mortality in mice infected by high
inoculum of influenza A/H5N1 virus. Proc Natl Acad Sci USA 105:8091–8096 [View Article]…

Efficacy of oseltamivir treatment in influenza virus-infected obese mice

R Honce, J Jones, VA Meliopoulos, B Livingston… - Mbio, 2023 - Am Soc Microbiol
… Thus, we questioned if oseltamivir treatment of OB mice would … In these studies, we
treated OB mice with the NAI oseltamivirmortality: a modelling study. Lancet 391:1285–1300. …

The effect of oseltamivir on the disease progression of lethal influenza A virus infection: plasma cytokine and miRNA responses in a mouse model

AK Chockalingam, S Hamed, DG Goodwin… - Disease …, 2016 - Wiley Online Library
… % mortality was observed on day 9 after infection. Prophylactic treatment with oseltamivir
significantly delayed mortality … treatment with oseltamivir significantly delayed mortality by 1 day …