10.7554/eLife.04580.001 Animals discriminate stimuli, learn their predictive value and use
this knowledge to modify their behavior. In Drosophila, the mushroom body (MB) plays a key …

Electrical silencing of Drosophila circadian pacemaker neurons through targeted expression
of K + channels causes severe deficits in free-running circadian locomotor rhythmicity in …

Nervous systems process information by integrating the electrical activity of neurons in
complex networks. This motivates the long-standing interest in using optical methods to …

Molecular genetics has revealed the identities of several components of the fundamental
circadian molecular oscillator — an evolutionarily conserved molecular mechanism of …

Coupling of autonomous cellular oscillators is an essential aspect of circadian clock
function but little is known about its circuit requirements. Functional ablation of the pigment-…

Neuropeptides modulate neural circuits controlling adaptive animal behaviors and physiological
processes, such as feeding/metabolism, reproductive behaviors, circadian rhythms, …

Genome biology approaches have made enormous contributions to our understanding of
biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and …

The ionotropic glutamate receptor (iGluR) gene family has been widely studied in animals
and is determined to be important in excitatory neurotransmission and other neuronal …

Circadian clocks are coupled to metabolic oscillations through nutrient-sensing pathways.
Nutrient flux into the hexosamine biosynthesis pathway triggers covalent protein modification …

Background Imbalances in amount and timing of sleep are harmful to physical and mental
health. Therefore, the study of the underlying mechanisms is of great biological importance. …