… To the best of our knowledge, the pharmacologic effects of paraxanthine in humans have
not … paraxanthine in humans and to compare the effects of paraxanthine with those of caffeine. …

This review provides a brief overview of known information on the human toxicity of theobromine
and paraxanthine. Theobromine has some pharmacological effects, although these …

… The paraxanthine/caffeine ratios in plasma and saliva … caffeine clearance from the
paraxanthine/caffeine ratios taken at any … In conclusion, the paraxanthine/caffeine ratios in plasma …

… CYP1A2 alone was responsible for caffeine 3-demethylation and paraxanthine 7-… The
metabolic profile of caffeine biotransformation by CYP1A2 averaged 81.5% for paraxanthine, 10.8…

… In a nested case–control study, we measured serum paraxanthine in 591 women who had
… the period from 1959 to 1966, and serum paraxanthine was measured over 30 years later. …

The microsomal metabolism of caffeine and its primary dimethylxanthine metabolites,
paraxanthine, theophylline, and theobromine, was investigated in 15 different human livers, …

… paraxanthine being the main metabolite in humans. In this study we show that in rats
paraxanthine … As previously described for caffeine, the locomotor activating doses of paraxanthine …

The pharmacokinetics of caffeine (CA), paraxanthine (PX), theobromine (TB) and
theophylline (TP) were studied in six healthy male volunteers after oral administration of each …

… An LC-MS/MS method for analysis of the model compounds caffeine and paraxanthine in …
a somewhat reduced recovery of caffeine and paraxanthine from VAMS tips at high hematocrit …

… paraxanthine), were selected for this study. Information for a total of 29,132 individual caffeine
and 7442 paraxanthine … concentrations (PNECs) for paraxanthine were higher than 5% for …