Small, DNA-containing particles were separated from preparations of a simian adenovirus.
These particles differed antigenically from the adenovirus. Replication of the particles in cell
cultures was obtained only when theywere inoculated simultaneously with adenoviruses …

The literature on cell transformation by chemical carcinogens has been critically reviewed.
This subject is highly relevant to carcinogenesis in vivo, because the phenotypic changes
that are collectively referred to as cell transformation usually involve the acquisition of …

Morphological transformation of Syrian hamster embryo cells was induced by direct
exposure to some inorganic salts of nickel, cadmium, chromium, beryllium, and arsenic but
not salts of iron, titanium, tungstate, zinc, aluminum, and nickel sulfide amorphous …

Thirty-eight metal salts were tested for their capacity to enhance transformation of Syrian
hamster embryo cells by a simian adenovirus, SA7. All of the metal salts with known
carcinogenic potential in animals or mutagenic activity in microbial or mammalian cells …

Reactive oxygen species (ROS) are a major cause of cellular injury in an increasing number
of diseases, including cancer. Most ROS are created in the cell through normal cellular
metabolism. They can be produced by environmental insults such as ultraviolet light and …

Abstract Oral cavity cancers represent 2.5% of the cancers that occur in the United States
and are ranked sixth worldwide. Since current therapeutic protocols are relatively ineffective,
alternative strategies for prevention need to be developed and tested in appropriate animal …

A number of genetic aberrations have been reported in end-stage squamous cell carcinoma
of the head and neck, including p16 INK4a and p14 ARF (INK4a/ARF) inactivation rates of
70–85%. Still, the cell cycle-regulatory genes p16 INK4a and p14 ARF remain poorly …

AAV type 1 has been shown to replicate in several species of cell cultures with the aid of
certain helper adenoviruses from man, monkey, mouse, and dog. However, during the
course of AAV replication the yield of the helper adenovirus was decreased. The reduction …

Treatment of hamster embryo cells with ultraviolet irradiation, 5-bromodeoxyuridine, 5-
iododeoxyuridine, 5-bromodeoxycytidine, or dibenz (a, h) anthracene prior to the addition of
an oncogenic adenovirus, SA7, enhanced the frequency of viral transformation among …

Treatment of hamster embryo cells with benzo (a) pyrene, 3-methylcholanthrene, 7, 12-
dimethylbenz (a) anthracene, dibenz (a, h) anthracene, or dibenz (a, c) anthracene for 18 hr
prior to the addition of an oncogenic adenovirus, SA7, enhanced the frequency of viral …