The HPA axis in major depression: classical theories and new developments - ScienceDirect Skip
to main content Skip to article Elsevier logo Journals & Books RegisterSign in Sign inRegister …

Perinatal mental disorders are associated with increased risk of psychological and
developmental disturbances in children. However, these disturbances are not inevitable. In …

Abstract% Hyperactivity of the hypothalamic–pituitary–adrenal (HPA) axis has been reliably
observed in patients with major depression. One of the primary features of this HPA axis …

Gene-environment interactions of FKBP5 and early trauma predict adult stress-related
psychiatric disorders. In this study, the authors reveal the molecular mechanism of how …

Stress in early life has been associated with insufficient glucocorticoid signaling in
adulthood, possibly affecting inflammation processes. Childhood maltreatment has been …

Objective To understand why children exposed to adverse psychosocial experiences are at
elevated risk for age-related disease, such as cardiovascular disease, by testing whether …

Background Pregnancy is a time of increased vulnerability for the development of anxiety
and depression. This systematic review aims to identify the main risk factors involved in the …

Major depressive disorder (MDD) is a debilitating disease that is characterized by
depressed mood, diminished interests, impaired cognitive function and vegetative …

Childhood trauma confers higher risk of adulthood physical and mental illness; however, the
biological mechanism mediating this association remains largely unknown. Recent research …

Context The association between depression and inflammation is inconsistent across
research samples. Objective To test whether a history of childhood maltreatment could …