Phagocytosis is a principal component of the body's innate immunity in which macrophages
internalize targets in an actin-dependent manner. Targets vary widely in shape and size and
include particles such as pathogens and senescent cells. Despite considerable progress in …

Encapsulation of therapeutic agents in polymer particles has been successfully used in the
development of new drug carriers. A number of design parameters that govern the functional
behavior of carriers, including the choice of polymer, particle size and surface chemistry …

Polymeric micro-and nanoparticles play a central role in varied applications such as drug
delivery, medical imaging, and advanced materials, as well as in fundamental studies in
fields such as microfluidics and nanotechnology. Functional behavior of polymeric particles …

Purpose Polymeric microspheres are extensively researched for applications in drug and
vaccine delivery. However, upon administration into the body, microspheres are primarily
cleared via phagocytosis by macrophages. Although numerous studies have reported on the …

Endocytosis in endothelial cells (ECs) is important for many biomedical applications,
including drug delivery by nano-and microscale carriers. However, little is known about how
carrier geometry influences endothelial drug targeting, intracellular trafficking, and effects …

Purpose To determine if particle shape can be engineered to inhibit phagocytosis of drug
delivery particles by macrophages, which can be a significant barrier to successful
therapeutic delivery. Methods Non-spherical polystyrene particles were fabricated by …

The sessile drop technique has been used to measure the contact angle of molten
aluminium, aluminium-nickel and aluminium-copper alloys, copper and gold, with sapphire,
ruby and recrystallised alumina. Measurements were made in vacuo, and as a function of …

Metabolic labeling of proteins with the methionine surrogate azidonorleucine can be
targeted exclusively to specified cells through expression of a mutant methionyl-tRNA
synthetase (MetRS). In complex cellular mixtures, proteins made in cells that express the …

The present invention generally relates to particles comprising hyaluronic acid, wherein the
particles are coated or encapsulated with a coating. The coating preferably comprises a
polymer, protein, polysaccharide, or combination thereof that decreases the rate of …

Compounds with the general formula Mo 1-x W x Se 2-y Te y have been prepared and their
crystal structure determined by x-ray analysis. Measurements near room temperature
indicate that most of the phases, with a structure similar to MoS 2, are p-type with a Seebeck …