Tramadol hydrochloride produced dose-related antinociception in mouse abdominal
constriction [ED50= 1.9 (1.2-2.6) mg/kg ip], hot-plate [48 degrees C, ED50= 21.4 (18.4-25.3)
mg/kg sc; 55 degrees C, ED50= 33.1 (28.2-39.1) mg/kg sc] and tail-flick [ED50= 22.8 (19.2 …

The explanation for the co-existence of opioid and nonopioid components of tramadol-
induced antinociception appears to be related to the different, but complementary and
interactive, pharmacologies of its enantiomers. The (+) enantiomer had Ki values of only …

Although it is well established that the analgesic effects of morphine are mediated by opioid
receptors, previous studies have shown that some opioids additionally inhibit the uptake of
serotonin and norepinephrine. The present investigation of a diverse group of opioids …

High throughput screening using the recombinant human TRPV1 receptor was used to
identify a series of pyridinylpiperazine ureas (3) as TRPV1 vanilloid receptor ligands.
Exploration of the structure− activity relationships by parallel synthesis identified the …

The voltage-gated calcium channel is composed of a pore-forming α 1 subunit and several
regulatory subunits: α 2 δ, β, and γ. We report here the identification of a novel α 2 δ subunit,
α 2 δ-4, from the expressed sequence tag database followed by its cloning and …

Abstract The drug SK&F 110679 (His-d-Trp-Ala-Trp-d-Phe-LysNH 2), is an enkephalin-
derived hexapeptide, which specifically releases growth hormone in a wide variety of
species in vivo and in vitro. Previous binding studies, using ligands which are specific for mu …

The voltage gated sodium channel comprises a pore‐forming α subunit and regulatory β
subunits. We report here the identification and characterization of a novel splicing variant of
the human β1 subunit, termed β1B. The 807 bp open reading frame of the human β1Β …

The purpose of this study was to evaluate the growth hormone (GH) releasing activity of
orally administered His-D-Trp-Ala-D-Phe-Lys-NH 2 (GHRP-6, SK&F 110679) in rats, dogs
and monkeys. Rats were administered GHRP-6 orally by gavage or parenterally through …

A method that allows the measurement of plasma and brain levels of the centrally-acting
analgesic tramadol and its major metabolite (O-desmethyl tramadol) in mice and rats was
developed using gas chromatography equipped with nitrogen–phosphorus detection (GC …

This invention relates to a pharmaceutical composition comprising a combination of a
tramadol material and an anticonvulsant drug and to the pharmacological use of the
composition in treating conditions of pain and neurologic or psychiatric disorders. The …