Synthetic lethal screen of an EGFR-centered network to improve targeted therapies
I Astsaturov, V Ratushny, A Sukhanova… - Sci. Signal …, 2010 - stke.sciencemag.org
Intrinsic and acquired cellular resistance factors limit the efficacy of most targeted cancer
therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes
closely linked to therapeutic targets would be enriched for determinants of drug resistance …
therapeutics. Synthetic lethal screens in lower eukaryotes suggest that networks of genes
closely linked to therapeutic targets would be enriched for determinants of drug resistance …
Electrosteric stabilization of colloidal latex dispersions
MB Einarson, JC Berg - Journal of colloid and interface science, 1993 - Elsevier
Experimental stability domains of monodisperse aqueous latices, with and without steric
stabilizers, are determined in terms of early-stage kinetics of flocculation using photon
correlation spectroscopy. Dispersion stability as a function of electrolyte concentration and …
stabilizers, are determined in terms of early-stage kinetics of flocculation using photon
correlation spectroscopy. Dispersion stability as a function of electrolyte concentration and …
The docking protein HEF1 is an apoptotic mediator at focal adhesion sites
SF Law, GM O'Neill, SJ Fashena… - … and cellular biology, 2000 - Am Soc Microbiol
ABSTRACT HEF1 (human enhancer of filamentation 1) is a member of a docking protein
family that includes p130 Cas and Efs. Through assembly of multiple protein interactions at
focal adhesion sites, these proteins activate signaling cascades in response to integrin …
family that includes p130 Cas and Efs. Through assembly of multiple protein interactions at
focal adhesion sites, these proteins activate signaling cascades in response to integrin …
Dissection of HEF1-dependent functions in motility and transcriptional regulation
SJ Fashena, MB Einarson, GM O'Neill… - Journal of cell …, 2002 - jcs.biologists.org
Cas-family proteins have been implicated as signaling intermediaries in diverse processes
including cellular attachment, motility, growth factor response, apoptosis and oncogenic
transformation. The three defined Cas-family members (p130Cas, HEF1/Cas-L and Efs/Sin) …
including cellular attachment, motility, growth factor response, apoptosis and oncogenic
transformation. The three defined Cas-family members (p130Cas, HEF1/Cas-L and Efs/Sin) …
Identification of a functional network of human epigenetic silencing factors
A Poleshko, MB Einarson, N Shalginskikh… - Journal of Biological …, 2010 - ASBMB
Epigenetic silencing is mediated by families of factors that place, remove, read, and transmit
repressive histone and DNA methylation marks on chromatin. How the roles for these
functionally diverse factors are specified and integrated is the subject of intense study. To …
repressive histone and DNA methylation marks on chromatin. How the roles for these
functionally diverse factors are specified and integrated is the subject of intense study. To …
Regulation of Id1 and its association with basic helix-loop-helix proteins during nerve growth factor-induced differentiation of PC12 cells.
MB Einarson, MV Chao - Molecular and cellular biology, 1995 - Am Soc Microbiol
Cell differentiation in the nervous system is dictated by specific patterns of gene expression.
We have investigated the role of helix-loop-helix (HLH) proteins during differentiation of
PC12 pheochromocytoma cells in response to nerve growth factor. Gel mobility shift assays …
We have investigated the role of helix-loop-helix (HLH) proteins during differentiation of
PC12 pheochromocytoma cells in response to nerve growth factor. Gel mobility shift assays …
[CITATION][C] Identification of protein-protein interactions with glutathione-S-transferase fusion proteins
MB Einarson, JR Orlinick - Protein-protein interactions: a molecular cloning …, 2002
[HTML][HTML] An RNA interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer
G Sethi, HB Pathak, H Zhang, Y Zhou, MB Einarson… - PLoS …, 2012 - journals.plos.org
Targeted therapies have been used to combat many tumor types; however, few have
effectively improved the overall survival in women with epithelial ovarian cancer, begging for
a better understanding of this deadly disease and identification of essential drivers of …
effectively improved the overall survival in women with epithelial ovarian cancer, begging for
a better understanding of this deadly disease and identification of essential drivers of …
Genome-wide siRNA screen reveals a new cellular partner of NK cell receptor KIR2DL4: heparan sulfate directly modulates KIR2DL4-mediated responses
M Brusilovsky, M Cordoba, B Rosental… - The Journal of …, 2013 - Am Assoc Immnol
KIR2DL4 (CD158d) is a distinct member of the killer cell Ig-like receptor (KIR) family in
human NK cells that can induce cytokine production and cytolytic activity in resting NK cells.
Soluble HLA-G, normally expressed only by fetal-derived trophoblast cells, was reported to …
human NK cells that can induce cytokine production and cytolytic activity in resting NK cells.
Soluble HLA-G, normally expressed only by fetal-derived trophoblast cells, was reported to …
Effect of salt on polymer solvency: implications for dispersion stability
MB Einarson, JC Berg - Langmuir, 1992 - ACS Publications
Polymer adsorption to a colloid surface has a wide range of practical applications. Whether
the presence of the adsorbed polymer acts to promote dispersion stability or to flocculate the
dispersion depends on the molecular weight, the amount adsorbed, the charge on the …
the presence of the adsorbed polymer acts to promote dispersion stability or to flocculate the
dispersion depends on the molecular weight, the amount adsorbed, the charge on the …
