RNA duplexes containing the modified base 2-amino-adenine in place of adenine are
stabilized through the formation of three hydrogen bonds in 2-amino A· U base pairs.
Antisense 2′-O-alkyloligorlbonucleotide probes incorporating 2-aminoadenosine are thus …

P72, a novel human member of the DEAD box family of putative RNA-dependent ATPases
and ATP-dependent RNA helicases was isolated from a HeLa cDNA library. The predicted
amino acid sequence of p72 is highly homologous to that of the prototypic DEAD box protein …

Pre-mRNA splicing is the process of removing intervening sequences (introns) from the
primary transcripts of protein coding genes. Splicing takes place in the nucleus and results
in the joining together of exon sequences to yield mature mRNA which is subsequently …

The synthesis of a modified 2′-deoxycytidine-3′-Ophosphoramidite carrying an Nt-
butylbenzoyl protected biotin on a long polar spacer arm attached to the 4-N position is
described. The presence of the bulky lipophilic t-butylbenzoyl protecting group enables the …

We describe a rapid and quantitative flow cytometric method for determining the apoptotic or
anti-apoptotic potential of a gene in various cell types. A plasmid carrying green fluorescent
protein (GFP) is co-transfected with an expression vector encoding the gene of interest …

The balance between tumor cell proliferation and apoptosis is a critical determinant of
malignant tumor outgrowth. In a transgenic mouse model of β cell tumorigenesis
(Rip1Tag2), insulin-like growth factor II (IGF-II) is up-regulated during the onset of tumor cell …

Hyperproliferation of tumor cells usually coincides with increased tumor cell apoptosis. To
overcome apoptosis, tumor cells frequently induce the expression of growth factors that
mediate cell survival. In nontransformed cells, including fibroblasts and neurons, survival …

The authors present their findings following an exhaustive literature review of research on
differentiated nursing practice (DNP) that used a number of tools to measure various aspects
of DNP that are applicable across the health care delivery continuum. Issues related to DNP …

• It is an open secret that innovation is driven by excellent basic research, and so it comes as
no surprise that commercial hubs for innovative technologies are primarily located around
renowned basic research institutes. In the USA, concentrated centres of innovative small …