Reproductive hormonal dynamics were assessed in 10 massively obese men, 200–380% of
ideal body weight (percentage ideal body weight) and 11 similarly-aged controls who were
85–135% of ideal body weight. The mean serum testosterone of the obese group was …

0 BESITY has become widespread in the US, with recent studies showing that 5% 39% of
Americans are obese.'Consequently, physicians are frequently required to perform
endocrine evaluations in obese subjects, not only to evaluate a possible endocrine cause …

Context: Drug-drug interactions are common but often are discovered only long after initial
drug release. Metformin has been available in the United States for 9 yr and elsewhere for
many years, but as of yet there are no reports that the drug modifies thyroid hormone …

In recent years, the endocrine aspects of obesity have assumed a prominent place in
consideration of the pathogenesis, diagnosis, prognosis, and treatment of obesity. Obesity
can lead to a variety of abnormalities in laboratory tests of endocrine function; knowledge of …

The effect of altered nutrition on sexual maturation may depend in part on the nature and
timing of the dietary change. The data are conflicting as to whether rats undernourished
before weaning but normally fed after weaning have delayed puberty, but such …

The hypothalamic-pituitary-testicular axis was evaluated in seven men with thyrotoxicosis
due to Graves' disease. Loss of libido and decreased potency were present in 71% and
56%, respectively. All patients had normal testicular volume (25 ml in all) and gynecomastia …

Gynecomastia is a common disorder that generally reflects an increased effective
estrogen/androgen ratio acting on the breast. It is usually idiopathic or related to normal
puberty, but medications are a frequent cause. Hypogonadism of any type may lead to …

THE treatment of hirsute women is controversial and often presents a therapeutic dilemma.
Mechanical methods (such as shaving or using depilatories) are safe but often unacceptable
to the patient, whereas suppression of adrenal or ovarian function may not be effective and …

Ten men with idiopathic oligospermia were treated with Ε1testolactone (Teslac), a potent
inhibitor of conversion of androgens to estrogens. Teslac therapy caused a fall in serum
estradiol and estrone levels of 34%(P< 0.01) and 41%(P< 0.01), respectively, and a rise in …

Women who exercise heavily may develop secondary amenorrhea. Since the mechanism of
so-called" runner's amenorrhea" has not been conclusively established, the authors
examined the occurrence of amenorrhea in one of the most intensively exercising groups of …