Silk from the silkworm, Bombyx mori, has been used as biomedical suture material for
centuries. The unique mechanical properties of these fibers provided important clinical
repair options for many applications. During the past 20 years, some biocompatibility …

Silks are fibrous proteins with remarkable mechanical properties produced in fiber form by
silkworms and spiders. Silk fibers in the form of sutures have been used for centuries.
Recently regenerated silk solutions have been used to form a variety of biomaterials, such …

Silk fibroin fiber scaffolds containing bone morphogenetic protein 2 (BMP-2) and/or
nanoparticles of hydroxyapatite (nHAP) prepared via electrospinning were used for in vitro
bone formation from human bone marrow-derived mesenchymal stem cells (hMSCs). BMP-2 …

Silk spinning by insects and spiders leads to the formation of fibres that exhibit high strength
and toughness 1. The lack of understanding of the protein processing in silk glands has
prevented the recapitulation of these properties in vitro from reconstituted or genetically …

A silk-fiber matrix was studied as a suitable material for tissue engineering anterior cruciate
ligaments (ACL). The matrix was successfully designed to match the complex and
demanding mechanical requirements of a native human ACL, including adequate fatigue …

Silk fibroin, derived from Bombyx mori cocoons, is a widely used and studied protein
polymer for biomaterial applications. Silk fibroin has remarkable mechanical properties
when formed into different materials, demonstrates biocompatibility, has controllable …

Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear
surfaces of biological tissues offer important opportunities for diagnosing and treating
disease and for improving brain/machine interfaces. This article describes a material …

Silks are being reassessed as biomaterial scaffolds due to their unique mechanical
properties, opportunities for genetic tailoring of structure and thus function, and recent
studies clarifying biocompatibility. We report on the covalent decoration of silk films with …

Silks are naturally occurring polymers that have been used clinically as sutures for centuries.
When naturally extruded from insects or worms, silk is composed of a filament core protein,
termed fibroin, and a glue-like coating consisting of sericin proteins. In recent years, silk …

A new all-aqueous process is described to form three-dimensional porous silk fibroin
matrices with control of structural and morphological features. The result of this process are
scaffolds with controllable porosity and pore sizes that fully degrade in the presence of …