Background. Over the past decade new insights in our understanding of coagulation have
identified the prominent role of tissue factor. The brain is rich in tissue factor, and injury to the
brain may initiate disturbances in local and systemic coagulation. We aimed to review the …

Background Working in the stressful environment of the Intensive Care Unit (ICU) is an
emotionally charged challenge that might affect the emotional stability of medical staff. The
quality of care for ICU patients and their relatives might be threatened through long-term …

Lactic acid was first found and described in sour milk by Karl Wilhelm Scheele (1742–1786)
in 1780. The German physician–chemist Johann Joseph Scherer (1841–1869)
demonstrated the occurrence of lactic acid in human blood under pathological conditions in …

Part of a large male woolly mammoth (Mammuthus primigenius) was preserved in
permafrost in northern Yakutia. It was radiocarbon dated to ca. 18,500 14 C yr BP (ca.
22,500 cal yr BP). Dung from the lower intestine was subjected to a multiproxy array of …

Background A considerable number of patients admitted to the intensive care unit (ICU) die
following withdrawal of mechanical ventilation. After discontinuation of ventilation without
proper preparation, excessive respiratory secretion is common, resulting in a 'death rattle' …

Background Successful donation of organs after cardiac death (DCD) requires identification
of patients who will die within 60 min of withdrawal of life-sustaining treatment (WLST). We
aimed to validate a straightforward model to predict the likelihood of death within 60 min of …

Abstract Purpose There is, in European countries that conduct medical chart review of
intensive care unit (ICU) deaths, no consensus on uniform criteria for defining a potential
organ donor. Although the term is increasingly being used in recent literature, it is seldom …

Important ethical aspects apply to the process of obtaining consent in emergency critical
care research: the incapacity of almost all patients for giving informed consent and the
emergency and life-threatening nature of the conditions involved, resulting in short …

Disproportionate care is common in western ICUs. It can lead to violation of basic bioethical
principles, suffering of patients and relatives and compassion fatigue and moral distress in
healthcare providers. Avoiding inappropriate use of ICU resources and disproportionate …

Objective To obtain insight into the occurrence of brain death and the potential for brain
dead and controlled non-heart-beating organ donors (CNHB) in patients with traumatic brain
injury (TBI), subarachnoid haemorrhage (SAH) and intracerebral haemorrhage (ICH) in a …