We created nanometer-scale transmembrane channels in lipid bilayers by means of self-
assembled DNA-based nanostructures. Scaffolded DNA origami was used to create a stem
that penetrated and spanned a lipid membrane, as well as a barrel-shaped cap that adhered …

Conspectus DNA has been previously shown to be useful as a material for the fabrication of
static nanoscale objects, and also for the realization of dynamic molecular devices and
machines. In many cases, nucleic acid assemblies directly mimic biological structures, for …

Spatial confinement from the nano-to the microscale is ubiquitous in nature. Striving to
understand the behavior of nanoscale objects in confined domains we present a nanofluidic
silicon device which consists of two stacked nanopores forming the in/outlets to a pyramidal …

We present a solid state nanopore device structure comprising two nanopores which are
stacked above each other and connected via a pyramidal cavity of 10 fl volume. The process
of fabrication of the pore–cavity–pore device (PCP) relies on the formation of one pore in a …

Electrophoretic transport through a solid-state nanodevice comprised of two stacked
nanopore sensors is used to determine the free-solution mobility of DNA molecules based
on their “time-of-flight” between the two pores. Mobility measurements are possible at very …

The stability of aptamer–ligand complexes is probed in nanopore-based dynamic force
spectroscopy experiments. Specifically, the ATP-binding aptamer is investigated using a
backward translocation technique, in which the molecules are initially pulled through an α …

Nucleosomes are the fundamental repeating units of chromatin, and dynamic regulation of
their positioning along DNA governs gene accessibility in eukaryotes. Although epigenetic
factors have been shown to influence nucleosome structure and dynamics, the impact of …

The aim of the present study was to investigate the influence of the response criterion, the
current well-being, and the speed of cognitive processing on fusion and flicker frequency
measured by method of limits, in 65 healthy subjects, aged between 20 and 30 years. The …

Spatial confinement from the nano-to the micro-scale is ubiquitous in nature. Striving to
emulate biological compartmentalization and to understand the fundamental physical
behavior of molecules in confined domains, micro-and nano-structuring techniques have …