Phagocytosis is a principal component of the body's innate immunity in which macrophages
internalize targets in an actin-dependent manner. Targets vary widely in shape and size and
include particles such as pathogens and senescent cells. Despite considerable progress in …

We report the design of surfaces that exhibit dynamic changes in interfacial properties, such
as wettability, in response to an electrical potential. The change in wetting behavior was
caused by surface-confined, single-layered molecules undergoing conformational …

The past twenty five years have seen an explosion in the creation and discovery of new
medicinal agents. Related innovations in drug delivery systems have not only enabled the
successful implementation of many of these novel pharmaceuticals, but have also permitted …

The development of biomaterials for drug delivery, tissue engineering and medical
diagnostics has traditionally been based on new chemistries. However, there is growing
recognition that the physical as well as the chemical properties of materials can regulate …

Encapsulation of therapeutic agents in polymer particles has been successfully used in the
development of new drug carriers. A number of design parameters that govern the functional
behavior of carriers, including the choice of polymer, particle size and surface chemistry …

Transdermal drug delivery offers a potential method of drug administration. However, its
application has been limited to a few low molecular weight compounds because of the
extremely low permeability of human skin. Low-frequency ultrasound was shown to increase …

Ultrasound, which is routinely used for diagnostic imaging applications, is now being
adopted in various drug delivery and other therapeutic applications. Ultrasound has been
shown to facilitate the delivery of drugs across the skin, promote gene therapy to targeted …

Applications of low-frequency (20 KHz) ultrasound enhances transdermal transport of high-
molecular weight proteins. This method includes a simultaneous application of ultrasound
and protein on the skin surface in order to deliver therapeutic doses of proteins across the …

Polymeric micro-and nanoparticles play a central role in varied applications such as drug
delivery, medical imaging, and advanced materials, as well as in fundamental studies in
fields such as microfluidics and nanotechnology. Functional behavior of polymeric particles …

Synthetic carriers such as polymer and lipid particles often struggle to meet clinical
expectations. Natural particulates—that range from pathogens to mammalian cells—are
therefore worth examining in more depth, as they are highly optimized for their specific …