Major depressive disorder (MDD) is a complex illness and it is likely that alterations in
several interacting systems underlie its pathogenesis. Numerous hypotheses have been …

The role for dysregulation of the immune system in the pathogenesis of depressive disorder
is well established, and emerging research suggests the role of an underlying genetic …

Background: End-stage liver disease is a common cause of morbidity and mortality
worldwide, yet little is known about its symptomatology and impact on health-related quality …

First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic–pituitary–
adrenal (HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study …

Background: Reduced brain-derived neurotrophic factor (BDNF) levels have been reported
in the serum and plasma of patients with psychosis. The aim of this cross-sectional case …

An inflammatory syndrome has been previously reported in chronic schizophrenia. The aims
of this study were to investigate:(1) serum levels and leukocyte gene expression of cytokines …

Sarcopenia and frailty are geriatric syndromes characterized by multisystem decline, which
are related to and reflected by markers of skeletal muscle dysfunction. In older people …

Increased sensitivity to stress is known to play an important role in the transition to first
episode psychosis (FEP). Hyperactivity of the hypothalamic-pituitary–adrenal (HPA) axis …

This study investigated the relationship between cortisol secretion and hippocampal volume
in first-episode psychosis and healthy controls. Hippocampal volume was measured by …

BackgroundCognitive impairment, particularly in memory and executive function, is a core
feature of psychosis. Moreover, psychosis is characterized by a more prominent history of …