Improved approaches for the detection of common epithelial malignancies are urgently
needed to reduce the worldwide morbidity and mortality caused by cancer. MicroRNAs
(miRNAs) are small (≈ 22 nt) regulatory RNAs that are frequently dysregulated in cancer …

T present, the orthodox view of the coupling A of phosphorylation to electron and hydrogen
transfer in oxidative and photosynthetic phosphorylation stems from knowledge of substrate-
level phosphorylationlyz. It is based, consequently, on the idea that water is expelled …

The processes of oxidative and photosynthetic phosphorylation, often alternatively
described as electron transport phosphorylation, consist of the flows of two sets of particles:
the oxido-reduction (o/r) particles (eg. 2H, H-or 2e-), and the hydrodehydration (h/d) …

The cloning of genes encoding mammalian DNA binding transcription factors for RNA
polymerase II has provided the opportunity to analyze the structure and function of these
proteins. This review summarizes recent studies that define structural domains for DNA …

Objective: To estimate the prevalence and distribution of age-related macular degeneration
(AMD) in the United States by age, race/ethnicity, and gender. Methods: Summary
prevalence estimates of drusen 125 µm or larger, neovascular AMD, and geographic …

Background Trials of endovascular therapy for ischemic stroke have produced variable
results. We conducted this study to test whether more advanced imaging selection, recently
developed devices, and earlier intervention improve outcomes. Methods We randomly …

Purpose Colorectal cancer is the second leading cause of cancer mortality in the United
States. Antiangiogenic therapy with bevacizumab combined with chemotherapy improves
survival in previously untreated metastatic colorectal cancer. This study was conducted to …

OBJECTIVES: To estimate the cause-specific prevalence and distribution of blindness and
low vision in the United States by age, race/ethnicity, and gender, and to estimate the
change in these prevalence figures over the next 20 years. METHODS: Summary …

The aim of this updated statement is to provide comprehensive and timely evidence-based
recommendations on the prevention of ischemic stroke among survivors of ischemic stroke
or transient ischemic attack. Evidence-based recommendations are included for the control …

MicroRNAs (miRNAs) circulate in the bloodstream in a highly stable, extracellular form and
are being developed as blood-based biomarkers for cancer and other diseases. However,
the mechanism underlying their remarkable stability in the RNase-rich environment of blood …