Human embryonic stem (hES) cells are pluripotent cell lines established from the explanted
inner cell mass of human blastocysts. Despite their importance for human embryology and
regenerative medicine, studies on hES cells, unlike those on mouse ES (mES) cells, have …

Somatic cell nuclear transfer (SCNT) technology has recently been used to generate
animals with a common genetic composition. In this study, we report the derivation of a
pluripotent embryonic stem (ES) cell line (SCNT-hES-1) from a cloned human blastocyst …

Patient-specific, immune-matched human embryonic stem cells (hESCs) are anticipated to
be of great biomedical importance for studies of disease and development, and to advance
clinical deliberations for stem cell transplantation. Eleven hESC lines were established by …

Picoplankton—cells with a diameter of less than 3 µm—are the dominant contributors to both
primary production and biomass in open oceanic regions 1, 2. However, compared with the
prokaryotes 3, the eukaryotic component of picoplankton is still poorly known. Recent …

Rho family small GTPases serve as molecular switches involved in the regulation of diverse
cellular functions including various cytoskeleton-related events and gene transcription. The
Rho GTPase-activating proteins (RhoGAPs) are one of the major classes of regulators of …

RhoA organizes actin stress fibres and is necessary for cell transformation by oncogenes
such as src and ras. Moreover, RhoA is implicated in cadherin clustering during the
formation of adherens junctions. The catenin p120 has also been implicated in cadherin …

Abstract The International Stem Cell Initiative analyzed 125 human embryonic stem (ES) cell
lines and 11 induced pluripotent stem (iPS) cell lines, from 38 laboratories worldwide, for
genetic changes occurring during culture. Most lines were analyzed at an early and late …

Human embryonic stem (hES) cells, due to their capacity of multipotency and self‐renewal,
may serve as a valuable experimental tool for human developmental biology and may
provide an unlimited cell source for cell replacement therapy. The purpose of this study was …

Pten (Phosphatase and tensin homolog deleted on chromosome 10) is a recently identified
tumor suppressor gene which is deleted or mutated in a variety of primary human cancers
and in three cancer predisposition syndromes [1]. Pten regulates apoptosis and cell cycle …

A new 8-hydroxyquinoline derivative having an appended boron− dipyrromethene function
has been prepared, and its metal ion sensing properties were investigated. The designed
compound exhibited pronounced Hg2+-selective on− off-type fluoroionophoric properties …