We have developed Textpresso, a new text-mining system for scientific literature whose
capabilities go far beyond those of a simple keyword search engine. Textpresso's two major
elements are a collection of the full text of scientific articles split into individual sentences …

We describe two classes of mutations in the lin-12 locus of the nematode Caenorhabditis
elegans. Ten semidominant mutations (lin-12 [d]) appear to elevate the level of lin-12
activity. Thirty-two recessive alleles (lin-12 [0]), including two amber mutations, appear to …

In addition to preventing crosstalk among related signaling pathways, scaffold proteins might
facilitate signal transduction by preforming multimolecular complexes that can be rapidly
activated by incoming signal. In many cases, such as mitogen-activated protein kinase …

The stereotyped mating behaviour of the Caenorhabditis elegans male is made up of
several substeps: response, backing, turning, vulva location, spicule insertion and sperm
transfer. The complexity of this behaviour is reflected in the sexually dimorphic anatomy and …

The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown
that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor
subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval …

Genetic analysis previously suggested that the let-60 gene controls the switch between
vulval and hypodermal cell fates during C. elegans vulval induction. We have cloned the let-
60 gene, and shown that it encodes a gene product identical in 84% of its first 164 amino …

Signaling via the epidermal growth factor (EGF)-receptor family is subject to regulation and
modulation by multiple ligands, effectors and negative regulators, as well as regulation by
heterodimerization between family members and crosstalk between heterologous signaling …

Previous studies have shown that the development of the vulva of the C. elegans
hermaphrodite involves six multipotential hypodermal cells as well as the gonadal anchor
cell, which induces vulval formation. Our further examination of the interactions among these …

The lin-3 gene is necessary for induction of the Caenorhabditis elegans vulva by the anchor
cell. It encodes a molecule similar to epidermal growth factor and to transforming growth
factor-a and acts through the epidermal growth factor receptor homologue let-23. Expression …

Twenty-three genes have been assigned to particular steps in a genetic pathway for the
specification of the vulval cell lineages of the nematode Caenorhabditis elegans. Mutations
in most of these genes cause homoeotic transformations in the fates of individual cells …