Hepatitis C virus (HCV) shows substantial nucleotide sequence diversity distributed
throughout the viral genome, with many variants showing only 68 to 79% overall sequence
similarity to one another. Phylogenetic analysis of nucleotide sequences derived from part of …

'Department of Medical Microbiology, Ilniversity of Edinburgh Medical School, Edinburgh
EH8 9AG, UK'Clinica Medica 2. lstituto di Medicina Clinica, Universita di Padova, 35123
Padova, Italy:" Immunology Section, Department of Transfution Medicine, Warren G …

Hepatitis C virus (HCV) is the main cause of parenteral non-A, non-B hepatitis and serum
can be tested for the virus itself by reverse-transcription polymerase chain amplificaton.
What of the level of this viraemia? To find out if quantitative study of H CV RNA might be …

The amino-acid sequence of the precursor of the human tumour cell line-derived platelet-
derived growth factor (PDGF) A-chain has been deduced from complementary DNA clones
and the gene localized to chromosome 7. The protein shows extensive homology to the …

Saccharomyces cerevisiae cells were transformed with plasmids containing hybrid genes in
which the sequence encoding mature human epidermal growth factor was joined to
sequences encoding the leader region (preprosegment) of the precursor of the yeast mating …

Linear or branched oligonucleotide multimers useful as amplifiers in biochemical assays
which comprise (1) at least one first single-stranded oligonucleotide unit that is
complementary to a single-stranded oligonucleotide sequence of interest, and (2) a …

We have determined the nucleotide sequence at the extreme 59 and 39 termini of the
hepatitis C virus (HCV) genome. Our analyses of these sequences show (i) the nucleotide
sequence in the 59 untranslated region is highly conserved among HCV isolates of widely …

Calmodulin was purified from Saccharomyces cerevisiae based on its characteristic
properties. Like other calmodulins, the yeast protein is small, heat-stable, acidic, retained by
hydrophobic matrices in a Ca 2+-dependent manner, exhibits a pronounced Ca 2+-induced …

Complementary DNA clones encoding the human kidney epidermal growth factor (EGF)
precursor have been isolated and sequenced. They predict the sequence of a 1,207 amino
acid protein which contains EGF flanked by polypeptide segments of 970 and 184 residues …

Isolates of hepatitis C virus (HCV) show considerable nucleotide sequence variability
throughout the genome. Comparisons of complete genome sequences have been used as
the basis of classification of HCV into a number of genotypes that show 67 to 77% sequence …