Background Increased peripheral inflammation has been consistently reported in patients
with major depressive disorder (MDD). However, only few studies have explored markers of …

Objective People with schizophrenia show a high incidence of metabolic syndrome, which is
associated with a high mortality from cardiovascular disease. The aetiology of the metabolic …

One of the most consistent findings in the biology of depression is an altered activity of the
hypothalamic–pituitary–adrenal (HPA) axis. However, data concerning this issue have never …

Childhood trauma confers higher risk of adulthood physical and mental illness; however, the
biological mechanism mediating this association remains largely unknown. Recent research …

Background People who use cannabis have an increased risk of psychosis an effect
attributed to the active ingredient δ9-tetrahydrocannabinol (Δ9-THC). There has recently …

Background The risk of individuals having adverse effects from drug use (eg, alcohol)
generally depends on the frequency of use and potency of the drug used. We aimed to …

Cannabis use is associated with an earlier age of onset of psychosis (AOP). However, the
reasons for this remain debated. Methods: We applied a Cox proportional hazards model to …

First-episode psychosis (FEP) patients show hyperactivity of the hypothalamic–pituitary–
adrenal (HPA) axis, but the mechanisms leading to this are still unclear. The aim of this study …

Background: Reduced brain-derived neurotrophic factor (BDNF) levels have been reported
in the serum and plasma of patients with psychosis. The aim of this cross-sectional case …

Background Cannabis use is associated with an increased risk of psychosis. One study has
suggested that genetic variation in the AKT1 gene might influence this effect. Methods In a …