Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
KW Ng, N Faulkner, GH Cornish, A Rosa… - …, 2020 - science.sciencemag.org
Zoonotic introduction of novel coronaviruses may encounter preexisting immunity in
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we
detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)–reactive
antibodies were detectable using a flow cytometry–based method in SARS-CoV-2–
uninfected individuals and were particularly prevalent in children and adolescents. They
were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit. By …
humans. Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, we
detected preexisting humoral immunity. SARS-CoV-2 spike glycoprotein (S)–reactive
antibodies were detectable using a flow cytometry–based method in SARS-CoV-2–
uninfected individuals and were particularly prevalent in children and adolescents. They
were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit. By …
Showing the best result for this search. See all results
