Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death

VJ Schuenemann, K Bos, S DeWitte… - Proceedings of the …, 2011 - National Acad Sciences
Although investigations of medieval plague victims have identified Yersinia pestis as the
putative etiologic agent of the pandemic, methodological limitations have prevented large-
scale genomic investigations to evaluate changes in the pathogen9s virulence over time.
We screened over 100 skeletal remains from Black Death victims of the East Smithfield mass
burial site (1348–1350, London, England). Recent methods of DNA enrichment coupled with
high-throughput DNA sequencing subsequently permitted reconstruction of ten full human …

[HTML][HTML] A draft genome of Yersinia pestis from victims of the Black Death

KI Bos, VJ Schuenemann, GB Golding, HA Burbano… - Nature, 2011 - nature.com
Technological advances in DNA recovery and sequencing have drastically expanded the
scope of genetic analyses of ancient specimens to the extent that full genomic investigations
are now feasible and are quickly becoming standard 1. This trend has important implications
for infectious disease research because genomic data from ancient microbes may help to
elucidate mechanisms of pathogen evolution and adaptation for emerging and re-emerging
infections. Here we report a reconstructed ancient genome of Yersinia pestis at 30-fold …
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