Estimating the rate of molecular evolution: incorporating non-contemporaneous sequences into maximum likelihood phylogenies
A Rambaut - Bioinformatics, 2000 - academic.oup.com
Motivation: TipDate is a program that will use sequences that have been isolated at different
dates to estimate their rate of molecular evolution. The program provides a maximum
likelihood estimate of the rate and also the associated date of the most recent common
ancestor of the sequences, under a model which assumes a constant rate of substitution
(molecular clock) but which accommodates the dates of isolation. Confidence intervals for
these parameters are also estimated. Results: The approach was applied to a sample of 17 …
dates to estimate their rate of molecular evolution. The program provides a maximum
likelihood estimate of the rate and also the associated date of the most recent common
ancestor of the sequences, under a model which assumes a constant rate of substitution
(molecular clock) but which accommodates the dates of isolation. Confidence intervals for
these parameters are also estimated. Results: The approach was applied to a sample of 17 …
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