Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder that
causes premature, rapid aging shortly after birth. Recently, de novo point mutations in the
Lmna gene have been found in individuals with HGPS. Lmna encodes lamin A and C, the A …

Progeria, the Hutchinson–Gilford progeria syndrome, is a rare disease of childhood with
striking features resembling premature aging (1–3). The syndrome is most likely caused by a
sporadic dominant new mutation in a gene that has yet to be identified. Progeria is unlikely …

Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare, uniformly fatal,
segmental “premature aging” disease in which children exhibit phenotypes that may give us
insights into the aging process at both the cellular and organismal levels. Initial presentation …

In an otherwise elegant clinical description of the Hutchinson–Gilford progeria syndrome by
Merideth and colleagues (Feb. 7 issue), 1 we take exception to the authors' suggestion that
their findings have overarching significance with respect to an understanding of normal …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by
features reminiscent of marked premature ageing 1, 2. Here, we present evidence of
mutations in lamin A (LMNA) as the cause of this disorder. The HGPS gene was initially …

Progeria is a rare genetic disorder characterized by premature aging, involving the skin,
bones, heart, and blood vessels. We report a 4-year-old boy who presented with clinical
manifestations of progeria. He had characteristic facies, prominent eyes, scalp and leg …

Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disorder, commonly
caused by a point mutation in the lamin A gene that results in a protein lacking 50 aa near
the C terminus, denoted LAΔ50. Here we show by light and electron microscopy that HGPS …

Hutchinson-Gilford progeria syndrome (HGPS) is a childhood premature aging disease
caused by a spontaneous point mutation in lamin A (encoded by LMNA), one of the major
architectural elements of the mammalian cell nucleus 1, 2, 3, 4. The HGPS mutation …

Hutchinson-Gilford progeria syndrome is an extremely rare condition of premature aging. It
is characterized by growth retardation and accelerated degenerative changes of cutaneous,
musculoskeletal and cardiovascular systems. The pathogenesis of the disease is unknown …

Background Hutchinson–Gilford progeria syndrome is a rare, sporadic, autosomal dominant
syndrome that involves premature aging, generally leading to death at approximately 13
years of age due to myocardial infarction or stroke. The genetic basis of most cases of this …