Although the sensitivity and specificity of the Duke criteria for the diagnosis of infective
endocarditis (IE) have been validated by investigators from Europe and the United States, several …

Brain function relies on communication between large populations of neurons across
multiple brain areas, a full understanding of which would require knowledge of the time-varying …

Schizophrenia and autism are thought to result from the interaction between a susceptibility
genotype and environmental risk factors. The offspring of women who experience infection …

A fundamental question in neuroscience is how entire neural circuits generate behaviour
and adapt it to changes in sensory feedback. Here we use two-photon calcium imaging to …

Atherosclerosis is driven by multifaceted contributions of the immune system within the
circulation and at vascular focal sites. However, specific characteristics of dysregulated immune …

Mucosal surfaces constantly encounter microbes. Toll-like receptors (TLRs) mediate
recognition of microbial patterns to eliminate pathogens. By contrast, we demonstrate that the …

Background— The goal of this statement was to review the available literature on surveillance,
screening, evaluation, and management strategies and put forward a scientific statement …

Background: Pompe disease is a progressive metabolic neuromuscular disorder resulting
from deficiency of lysosomal acid α-glucosidase (GAA). Infantile-onset Pompe disease is …

Background Treatment of acute Kawasaki disease with intravenous immune globulin and
aspirin reduces the risk of coronary-artery abnormalities and systemic inflammation, but …

Endothelial to mesenchymal transition (EndMT) plays a major role during development, and
also contributes to several adult cardiovascular diseases. Importantly, mesenchymal cells …