Nutzerprofile für Karoly Mirnics
Karoly Mirnics, MD, PhDHattie B. Munroe Professor, Director of Munroe-Meyer Institute for Genetics and Rehab at … Bestätigte E-Mail-Adresse bei unmc.edu Zitiert von: 17881 |
Maternal immune activation alters fetal brain development through interleukin-6
Schizophrenia and autism are thought to result from the interaction between a susceptibility
genotype and environmental risk factors. The offspring of women who experience infection …
genotype and environmental risk factors. The offspring of women who experience infection …
Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …
[HTML][HTML] Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice
…, J Robinson, YP Tang, IS Hairston, Z Korade-Mirnics… - Cell, 2005 - cell.com
Cerebral deposition of β-amyloid (Aβ) peptides is an invariant pathological hallmark in brains
of patients with Alzheimer's disease (AD) and transgenic mice coexpressing familial AD-…
of patients with Alzheimer's disease (AD) and transgenic mice coexpressing familial AD-…
Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia
…, DW Volk, SM Eggan, K Mirnics… - Journal of …, 2003 - Soc Neuroscience
Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects
with schizophrenia, and several lines of evidence suggest that these alterations may be …
with schizophrenia, and several lines of evidence suggest that these alterations may be …
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients
Objective Degeneration of chronically demyelinated axons is a major cause of irreversible
neurological disability in multiple sclerosis (MS) patients. Development of neuroprotective …
neurological disability in multiple sclerosis (MS) patients. Development of neuroprotective …
Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation
Children exposed to early parental loss from death or separation carry a greater risk for
developing future psychiatric illnesses, such as major depression and anxiety. Monkeys …
developing future psychiatric illnesses, such as major depression and anxiety. Monkeys …
Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia
FA Middleton, K Mirnics, JN Pierri… - Journal of …, 2002 - Soc Neuroscience
Dysfunction of the dorsal prefrontal cortex (PFC) in schizophrenia may be associated with
alterations in the regulation of brain metabolism. To determine whether abnormal expression …
alterations in the regulation of brain metabolism. To determine whether abnormal expression …
Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia
T Hashimoto, HH Bazmi, K Mirnics… - American Journal of …, 2008 - Am Psychiatric Assoc
Objective: Individuals with schizophrenia exhibit disturbances in a number of cognitive, affective,
sensory, and motor functions that depend on the circuitry of different cortical areas. The …
sensory, and motor functions that depend on the circuitry of different cortical areas. The …
Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse
The level of cellular and molecular complexity of the nervous system creates unique problems
for the neuroscientist in the design and implementation of functional genomic studies. …
for the neuroscientist in the design and implementation of functional genomic studies. …
Immune transcriptome alterations in the temporal cortex of subjects with autism
…, PJ Ebert, A Mitchell, C Lintas, B Manzi, K Mirnics… - Neurobiology of …, 2008 - Elsevier
Autism is a severe disorder that involves both genetic and environmental factors. Expression
profiling of the superior temporal gyrus of six autistic subjects and matched controls …
profiling of the superior temporal gyrus of six autistic subjects and matched controls …