Nutzerprofile für Karoly Mirnics

Karoly Mirnics, MD, PhD

Hattie B. Munroe Professor, Director of Munroe-Meyer Institute for Genetics and Rehab at …
Bestätigte E-Mail-Adresse bei unmc.edu
Zitiert von: 17881

Maternal immune activation alters fetal brain development through interleukin-6

SEP Smith, J Li, K Garbett, K Mirnics… - Journal of …, 2007 - Soc Neuroscience
Schizophrenia and autism are thought to result from the interaction between a susceptibility
genotype and environmental risk factors. The offspring of women who experience infection …

Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex

K Mirnics, FA Middleton, A Marquez, DA Lewis, P Levitt - Neuron, 2000 - cell.com
Microarray expression profiling of prefrontal cortex from matched pairs of schizophrenic and
control subjects and hierarchical data analysis revealed that transcripts encoding proteins …

[HTML][HTML] Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice

…, J Robinson, YP Tang, IS Hairston, Z Korade-Mirnics… - Cell, 2005 - cell.com
Cerebral deposition of β-amyloid (Aβ) peptides is an invariant pathological hallmark in brains
of patients with Alzheimer's disease (AD) and transgenic mice coexpressing familial AD-…

Gene expression deficits in a subclass of GABA neurons in the prefrontal cortex of subjects with schizophrenia

…, DW Volk, SM Eggan, K Mirnics… - Journal of …, 2003 - Soc Neuroscience
Markers of inhibitory neurotransmission are altered in the prefrontal cortex (PFC) of subjects
with schizophrenia, and several lines of evidence suggest that these alterations may be …

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

…, DA Lewis, RJ Fox, R Rudick, K Mirnics… - Annals of …, 2006 - Wiley Online Library
Objective Degeneration of chronically demyelinated axons is a major cause of irreversible
neurological disability in multiple sclerosis (MS) patients. Development of neuroprotective …

Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation

…, DA Lewis, P Levitt, JL Cameron, K Mirnics - Journal of …, 2007 - Soc Neuroscience
Children exposed to early parental loss from death or separation carry a greater risk for
developing future psychiatric illnesses, such as major depression and anxiety. Monkeys …

Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia

FA Middleton, K Mirnics, JN Pierri… - Journal of …, 2002 - Soc Neuroscience
Dysfunction of the dorsal prefrontal cortex (PFC) in schizophrenia may be associated with
alterations in the regulation of brain metabolism. To determine whether abnormal expression …

Conserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia

T Hashimoto, HH Bazmi, K Mirnics… - American Journal of …, 2008 - Am Psychiatric Assoc
Objective: Individuals with schizophrenia exhibit disturbances in a number of cognitive, affective,
sensory, and motor functions that depend on the circuitry of different cortical areas. The …

Analysis of complex brain disorders with gene expression microarrays: schizophrenia as a disease of the synapse

K Mirnics, FA Middleton, DA Lewis, P Levitt - Trends in neurosciences, 2001 - cell.com
The level of cellular and molecular complexity of the nervous system creates unique problems
for the neuroscientist in the design and implementation of functional genomic studies. …

Immune transcriptome alterations in the temporal cortex of subjects with autism

…, PJ Ebert, A Mitchell, C Lintas, B Manzi, K Mirnics… - Neurobiology of …, 2008 - Elsevier
Autism is a severe disorder that involves both genetic and environmental factors. Expression
profiling of the superior temporal gyrus of six autistic subjects and matched controls …