Schizophrenia and autism are thought to result from the interaction between a susceptibility
genotype and environmental risk factors. The offspring of women who experience infection …

Autism is a severe disorder that involves both genetic and environmental factors. Expression
profiling of the superior temporal gyrus of six autistic subjects and matched controls …

We are exploring the mechanisms underlying how maternal infection increases the risk for
schizophrenia and autism in the offspring. Several mouse models of maternal immune …

Presenilins 1 and 2 (PS1 and PS2) are the catalytic subunits of the γ-secretase complex, and
genes encoding mutant PS1 and PS2 variants cause familial forms of Alzheimer's disease. …

Reduced expression of the Gad1 gene-encoded 67-kDa protein isoform of glutamic acid
decarboxylase (GAD67) is a hallmark of schizophrenia. GAD67 downregulation occurs in …

We previously defined Saccharomyces cerevisiae TFIID as a 15-subunit complex comprised
of the TATA binding protein (TBP) and 14 distinct TBP-associated factors (TAFs). In this …

Maternal inflammation and diabetes increase the risk for psychiatric disorders in offspring.
We hypothesized that these co-occurring risk factors may potentiate each other. To test this, …

In vivo studies have previously shown that Saccharomyces cerevisiae ribosomal protein (RP)
gene expression is controlled by the transcription factor repressor activator protein 1 (…

… Author links open overlay panel Krassimira A. Garbett a , Andrea Vereczkei a b , Sára
Kálmán a c , Jacquelyn A. Brown a , Warren D. Taylor a , Gábor Faludi d , Željka Korade a f , …

Autism is a highly heterogeneous neurodevelopmental disorder with impaired language,
social communication, and restricted and repetitive interests and behavior. Monogenic …