… determine the oscillatory synthesis of NAMPT, the key enzyme in the NAD + salvage pathway …
The NAD + -dependent deacetylase SIRT1 is thereby controlling the oscillatory synthesis of its …
Specifically, are metabolic pathways regulating the circadian machinery (3, 25, 26), or …

… genetic evidence for the existence of several additional pathways for salvaging the nicotinamide
ring of … in the budding yeast Saccharomyces cerevisiae (Figure 1). Both pathways salvage the
nicotinamide ring for entry into established pathways of NAD + synthesis …

… An uncharacterized ORF, QNS1/YHR074, shows high homolgy to NAD synthetases. Each … through
most metabolic pathways is controled by multiple enzymes, rather than by a single rate-liming
step (62). Of all the genes in the salvage pathway, only QNS1 had no …

Nicotinamide adenine dinucleotide (NAD) is a critical metabolite that is required for a range
of cellular reactions. A key enzyme in the NAD salvage pathway is nicotinamide
phosphoribosyl transferase (NAMPT), and here, we describe GNE-618, an NAMPT inhibitor …

… Interestingly, the activation of the NAD salvage pathway in yeast does not alter total cellular NAD
levels … and pathological processes in the nervous system through SIRT1-dependent pathways
(28 … that the alteration of NAD levels by manipulation of the NAD biosynthetic pathway …

Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide
phosphate (NADP), which is derived from NAD, have important roles as a redox carriers in
metabolism. A combination of de novo and salvage pathways contribute to the biosynthesis …

… To explore the latter hypothesis, we focused on PNC1, a gene whose product converts
nicotinamide to nicotinic acid in the NAD + salvage pathway (Fig … In S. cerevisiae, the only other
NAD + salvage pathway gene that can be deleted without a loss of viability is NPT1 (see Fig …

… The NAMPT enzyme controls the rate-limiting step in the NAD salvage pathway (Preiss and
Handler, 1958). NAMPT is an obligate dimer whose molecular structure has been resolved
by X-ray crystallography (Khan et al., 2006; Wang et al., 2006) …

… 1 ENZYMES IN THE NAD + SALVAGE PATHWAY REGULATE SIRT1 ACTIVITY AT TARGET
GENE PROMOTERS … TGFB2, SOCS2 and PEG10 function in cytokine signaling pathways, but
PEG10 … These results suggest that the NAD+- salvage pathway and NAD+-dependent …

… Metabolic and signalling reactions of nicotinamide adenine dinucleotide (phosphate) [NAD(P)]
are shown in Figure I. NAD synthesis is commonly divided into the de novo and the salvage
pathways. The NAD precursors of the salvage pathway are the degradation products of …