Maternal viral infection is known to increase the risk for schizophrenia and autism in the
offspring. Using this observation in an animal model, we find that respiratory infection of …

Neurodevelopmental disorders, including autism spectrum disorder (ASD), are defined by
core behavioral impairments; however, subsets of individuals display a spectrum of …

Schizophrenia and autism are thought to result from the interaction between a susceptibility
genotype and environmental risk factors. The offspring of women who experience infection …

Cytokines are pleotrophic proteins that coordinate the host response to infection as well as
mediate normal, ongoing signaling between cells of nonimmune tissues, including the …

There is increasing evidence of immune involvement in both schizophrenia and autism. Of
particular interest are striking abnormalities in the expression of immune-related molecules …

The core symptoms of autism are deficits in social interaction and language, and the
presence of repetitive/stereotyped behaviors. We demonstrate that behaviors related to these …

Recent studies have highlighted a connection between infection during pregnancy and the
increased risk of autism in the offspring. Parallel studies of cerebral spinal fluid, blood and …

Brain injury, genetic manipulations, and pharmacological treatments can result in alterations
of motor skills in mice. Fine motor coordination and balance can be assessed by the beam …

Neuropoietic cytokines are well known for their role in the control of neuronal, glial and immune
responses to injury or disease. Since this discovery, it has emerged that several of these …

Expansion of the polyglutamine repeat within the protein Huntingtin (Htt) causes Huntington's
disease, a neurodegenerative disease associated with aging and the accumulation of …