This international guideline proposes improving clozapine package inserts worldwide by
using ancestry-based dosing and titration. Adverse drug reaction (ADR) databases suggest …

Phenoconversion is a phenomenon that converts genotypic extensive metabolizers ( EM s)
into phenotypic poor metabolizers ( PM s) of drugs, thereby modifying their clinical response …

Phenoconversion transiently converts genotypic extensive metabolizers (EMs) into phenotypic
poor metabolizers (PMs) of drugs, potentially with corresponding changes in clinical …

… Edited by ROBERT L. SMITH … Finally, I thank Jill Smith, who spent many hours typesetting
the text, drafting figures, and generally attending to details of the book’s production. …

… When we first introduced the term resurgent cauldron (Smith and Bailey, 1962), we were so
strongly influenced by the apparent similarity of the Valles and Toba domes that we included …

Methods: Over a 2-year period at a university hospital, data on all elective colorectal resections
performed by a single surgeon were retrospectively collected. The outcome of interest …

We consider the Monte Carlo problem of generating points uniformly distributed within an
arbitrary bounded (measurable) region. The class of Markovian methods considered generate …

We consider the problem of individual route guidance in an Intelligent Vehicle-Highway
Systems (IVHS ) environment, based on time-dependent forecasts of link travel time. We …

FOXP2, the first gene to have been implicated in a developmental communication disorder,
offers a unique entry point into neuromolecular mechanisms influencing human speech and …

To acquire transforming potential, the precursor of the Ras oncoprotein must undergo
farnesylation of the cysteine residue located in a carboxyl-terminal tetrapeptide. Inhibitors of the …